RNA-directed DNA methylation: an epigenetic pathway of increasing complexity

被引：1129

作者：

Matzke, Marjori A. ^{[1
]}

Mosher, Rebecca A. ^{[2
]}

机构：

[1] Acad Sinica, Inst Plant & Microbial Biol, Taipei 115, Taiwan

[2] Univ Arizona, Sch Plant Sci, Tucson, AZ 85721 USA

来源：

NATURE REVIEWS GENETICS | 2014年 / 15卷 / 06期

基金：

美国国家科学基金会;

关键词：

IV-DEPENDENT SIRNAS; DE-NOVO METHYLATION; POL-IV; POLYMERASE-IV; GENE-EXPRESSION; TRANSPOSABLE ELEMENTS; SILENCING SIGNAL; MUTANTS REVEALS; NONCODING RNA; ARABIDOPSIS;

D O I：

10.1038/nrg3683

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

RNA-directed DNA methylation (RdDM) is the major small RNA-mediated epigenetic pathway in plants. RdDM requires a specialized transcriptional machinery that comprises two plant-specific RNA polymerases - Pot IV and Pot V - and a growing number of accessory proteins, the functions of which in the RdDM mechanism are only partially understood. Recent work has revealed variations in the canonical RdDM pathway and identified factors that recruit Pot IV and Pol V to specific target sequences. RdDM, which transcriptionally represses a subset of transposons and genes, is implicated in pathogen defence, stress responses and reproduction, as well as in interallelic and intercellular communication.

引用

页码：394 / 408

页数：15

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