Building a new conceptual framework for receptor heteromers

被引：294

作者：

Ferre, Sergi ^{[1
]}

Baler, Ruben ^{[2
]}

Bouvier, Michel ^{[3
]}

Caron, Marc G. ^{[4
]}

Devi, Lakshmi A. ^{[5
]}

Durroux, Thierry ^{[6
]}

Fuxe, Kjell ^{[7
]}

George, Susan R. ^{[8
]}

Javitch, Jonathan A. ^{[9
]}

Lohse, Martin J. ^{[10
]}

Mackie, Ken ^{[11
]}

Milligan, Graeme ^{[12
]}

Pfleger, Kevin D. G. ^{[13
,14
]}

Pin, Jean-Philippe ^{[15
]}

Volkow, Nora D. ^{[16
]}

Waldhoer, Maria ^{[17
]}

Woods, Amina S. ^{[18
]}

Franco, Rafael ^{[19
,20
]}

机构：

[1] NIH, Natl Inst Drug Abuse, IRP, DHHS, Baltimore, MD 21224 USA

[2] NIH, Natl Inst Drug Abuse, DHHS, Bethesda, MD 20892 USA

[3] Univ Montreal, Inst Res Immunol & Canc, Montreal, PQ H3C 3J7, Canada

[4] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA

[5] Mt Sinai Sch Med, New York, NY 10029 USA

[6] Univ Montpellier, INSERM, CNRS, Inst Genom Fonct, F-34000 Montpellier, France

[7] Karolinska Inst, S-17177 Stockholm, Sweden

[8] Univ Toronto, Ctr Addict & Mental Hlth, Toronto, ON M5S 1A8, Canada

[9] Columbia Univ, Ctr Mol Recognit, Coll Phys & Surg, New York, NY 10032 USA

[10] Univ Wurzburg, Rudolf Virchow Ctr, D-97078 Wurzburg, Germany

[11] Indiana Univ, Bloomington, IN 47405 USA

[12] Univ Glasgow, Glasgow G12 8QQ, Lanark, Scotland

[13] Univ Western Australia, Western Australian Inst Med Res, Nedlands, WA 6009, Australia

[14] Univ Western Australia, Med Res Ctr, Nedlands, WA 6009, Australia

[15] Univ Montpellier, INSERM, CNRS, Inst Genom Fonct, F-34000 Montpellier, France

[16] NIH, Natl Inst Drug Abuse, DHHS, Bethesda, MD 20892 USA

[17] Med Univ Graz, A-8010 Graz, Austria

[18] NIH, Natl Inst Drug Abuse, IRP, DHHS, Baltimore, MD 21224 USA

[19] Univ Barcelona, IDIBAPS Fac Biol, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona 08028, Spain

[20] Univ Navarra, CIMA, Pamplona 31008, Spain

来源：

NATURE CHEMICAL BIOLOGY | 2009年 / 5卷 / 03期

基金：

英国医学研究理事会;

关键词：

PROTEIN-COUPLED RECEPTORS; INTERNATIONAL UNION; PHARMACOLOGY; RELEVANCE; HETERODIMERIZATION; CLASSIFICATION; IDENTIFICATION; NOMENCLATURE; MODULATION; STRIATUM;

D O I：

10.1038/nchembio0309-131

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Receptor heteromers constitute a new area of research that is reshaping our thinking about biochemistry, cell biology, pharmacology and drug discovery. In this commentary, we recommend clear definitions that should facilitate both information exchange and research on this growing class of transmembrane signal transduction units and their complex properties. We also consider research questions underlying the proposed nomenclature, with recommendations for receptor heteromer identification in native tissues and their use as targets for drug development.

引用

页码：131 / 134

页数：4

共 30 条

[1] Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons [J].

Agnati, LF ;

Ferré, S ;

Lluis, C ;

Franco, R ;

Fuxe, K .

PHARMACOLOGICAL REVIEWS, 2003, 55 (03) :509-550

[2] The GDNF family: Signalling, biological functions and therapeutic value [J].

Airaksinen, MS ;

Saarma, M .

NATURE REVIEWS NEUROSCIENCE, 2002, 3 (05) :383-394

[3] Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation [J].

Bulenger, S ;

Marullo, S ;

Bouvier, M .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2005, 26 (03) :131-137

[4] Detection of heteromerization of more than two proteins by sequential BRET-FRET [J].

Carriba, Paulina ;

Navarro, Gemma ;

Ciruela, Francisco ;

Ferre, Sergi ;

Casado, Vicent ;

Agnati, Luigi ;

Cortes, Antoni ;

Mallol, Josefa ;

Fuxe, Kjell ;

Canela, Enric I. ;

Lluis, Carmen ;

Franco, Rafael .

NATURE METHODS, 2008, 5 (08) :727-733

[5] Neurotrophins and their receptors: A convergence point for many signalling pathways [J].

Chao, MV .

NATURE REVIEWS NEUROSCIENCE, 2003, 4 (04) :299-309

[6] Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series [J].

Daniels, DJ ;

Lenard, NR ;

Etienne, CL ;

Law, PY ;

Roerig, SC ;

Portoghese, PS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (52) :19208-19213

[7]

Dingledine R, 1999, PHARMACOL REV, V51, P7

[8] Functional relevance of neurotransmitter receptor heteromers in the central nervous system [J].

Ferre, Sergi ;

Ciruela, Francisco ;

Woods, Amina S. ;

Lluis, Carme ;

Franco, Rafael .

TRENDS IN NEUROSCIENCES, 2007, 30 (09) :440-446

[9] Dimer-based model for heptaspanning membrane receptors [J].

Franco, R ;

Casadó, V ;

Mallol, J ;

Ferré, S ;

Fuxe, K ;

Cortés, A ;

Ciruela, F ;

Lluis, C ;

Canela, EI .

TRENDS IN BIOCHEMICAL SCIENCES, 2005, 30 (07) :360-366

[10] Identification of a serotonin/glutamate receptor complex implicated in psychosis [J].

Gonzalez-Maeso, Javier ;

Ang, Rosalind L. ;

Yuen, Tony ;

Chan, Pokman ;

Weisstaub, Noelia V. ;

Lopez-Gimenez, Juan F. ;

Zhou, Mingming ;

Okawa, Yuuya ;

Callado, Luis F. ;

Milligan, Graeme ;

Gingrich, Jay A. ;

Filizola, Marta ;

Meana, J. Javier ;

Sealfon, Stuart C. .

NATURE, 2008, 452 (7183) :93-U9

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