Lymphocyte-to-monocyte ratio in predicting the calcific aortic valve stenosis in a Chinese case-control study

被引：0

作者：

Ma, Xiaochun ^{[1
,2
]}

Ma, Huibo ^{[3
]}

Yun, Yan ^{[4
]}

Chen, Shanghao ^{[1
,2
]}

Zhang, Xiaofeng ^{[5
]}

Zhao, Diming ^{[1
,2
]}

Liu, Yanwu ^{[1
,2
]}

Shen, Hechen ^{[1
,2
]}

Wu, Chuanni ^{[1
,2
]}

Zheng, Jing ^{[1
,2
]}

Zhang, Tao ^{[1
,2
]}

Xu, Zhenqiang ^{[1
,2
]}

Sun, Liangong ^{[1
,2
]}

Zhang, Haizhou ^{[1
,2
]}

Zhang, Wenlong ^{[1
,2
]}

Zou, Chengwei ^{[1
,2
]}

Wang, Zhengjun ^{[1
,2
]}

机构：

[1] Shandong First Med Univ, Shandong Prov Hosp, Dept Cardiovasc Surg, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China

[2] Shandong Univ, Shandong Prov Hosp, Dept Cardiovasc Surg, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China

[3] Qingdao Univ, Med Coll, 308 Ningxia Rd, Qingdao 266071, Shandong, Peoples R China

[4] Shandong Univ, Qilu Hosp, Dept Radiol, 107 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China

[5] Shandong Univ, Hosp 2, Dept Cardiovasc Surg, 247 Beiyuan Rd, Jinan 250033, Shandong, Peoples R China

来源：

BIOMARKERS IN MEDICINE | 2020年 / 14卷 / 14期

基金：

国家重点研发计划;

关键词：

calcific aortic valve stenosis; lymphocyte-to-monocyte ratio; INFLAMMATION; NEUTROPHIL; MECHANISMS; PROGNOSIS; SEVERITY;

D O I：

10.2217/bmm-2020-0228

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim:This study examined the role of lymphocyte-to-monocyte ratio (LMR), an inflammatory biomarker, in predicting the severity of calcific aortic valve stenosis (CAVS) in a Chinese case-control study.Results:The LMR significantly decreased in the patients with CAVS compared with healthy controls. An inverse correlation was observed between the severity of stenosis and LMR in the patients. Additionally, the LMR was identified in the multivariate analysis as an independent predictor of severe CAVS.Conclusion:This study provides evidence of an inverse correlation between the severity of CAVS and LMR. LMR could potentially be applied as an independent predictor of severe CAVS and could be incorporated into a novel predictive model.

引用

页码：1329 / 1339

页数：11

共 36 条

[1] Early aortic valve inflammation precedes calcification: A longitudinal FDG-PET/CT study [J].

Abdelbaky, Amr ;

Corsini, Erin ;

Figueroa, Amparo L. ;

Subramanian, Sharath ;

Fontanez, Sara ;

Emami, Hamed ;

Hoffmann, Udo ;

Narula, Jagat ;

Tawakol, Ahmed .

ATHEROSCLEROSIS, 2015, 238 (02) :165-172

[2] Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo [J].

Aikawa, Elena ;

Nahrendorf, Matthias ;

Figueiredo, Jose-Luiz ;

Swirski, Filip K. ;

Shtatland, Timur ;

Kohler, Rainer H. ;

Jaffer, Farouc A. ;

Aikawa, Masanori ;

Weissleder, Ralph .

CIRCULATION, 2007, 116 (24) :2841-2850

[3] A Rock and a Hard Place Chiseling Away at the Multiple Mechanisms of Aortic Stenosis [J].

Aikawa, Elena ;

Libby, Peter .

CIRCULATION, 2017, 135 (20) :1951-1955

[4] Neutrophil-to-lymphocyte ratio is increased in patients with rheumatic mitral valve stenosis? [J].

Akboga, Mehmet Kadri ;

Akyel, Ahmet ;

Sahinarslan, Asife ;

Yayla, Cagri ;

Alsancak, Yakup ;

Gokalp, Gokhan ;

Nurkoc, Serdar ;

Abaci, Adnan .

ANATOLIAN JOURNAL OF CARDIOLOGY, 2015, 15 (05) :380-384

[5] The Relationship between Neutrophil/Lymphocyte Ratio and Calcific Aortic Stenosis [J].

Avci, Anil ;

Elnur, Alizade ;

Goksel, Acar ;

Serdar, Fidan ;

Servet, Izci ;

Atilla, Koyuncu ;

Mustafa, Tabakci Mehmet ;

Cuneyt, Toprak ;

Yeliz, Guler ;

Mustafa, Bulut ;

Metin, Esen Ali .

ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, 2014, 31 (09) :1031-1035

[6] Transcatheter or surgical treatment of severe aortic stenosis and coronary artery disease: A comparative analysis from the Italian OBSERVANT study [J].

Barbanti, Marco ;

Buccheri, Sergio ;

Capodanno, Davide ;

D'Errigo, Paola ;

Ranucci, Marco ;

Rosato, Stefano ;

Santoro, Gennaro ;

Fusco, Danilo ;

Tamburino, Corrado ;

Biancari, Fausto ;

Seccareccia, Fulvia .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2018, 270 :102-106

[7] Refining Molecular Pathways Leading to Calcific Aortic Valve Stenosis by Studying Gene Expression Profile of Normal and Calcified Stenotic Human Aortic Valves [J].

Bosse, Yohan ;

Miqdad, Ahmed ;

Fournier, Dominique ;

Pepin, Andree ;

Pibarot, Philippe ;

Mathieu, Patrick .

CIRCULATION-CARDIOVASCULAR GENETICS, 2009, 2 (05) :489-U185

[8] Inflammatory and metabolic mechanisms underlying the calcific aortic valve disease [J].

Cho, Kyoung Im ;

Sakuma, Ichiro ;

Sohn, Il Suk ;

Jo, Sang-Ho ;

Koh, Kwang Kon .

ATHEROSCLEROSIS, 2018, 277 :60-65

[9] Inflammation Is Associated with the Remodeling of Calcific Aortic Valve Disease [J].

Cote, Nancy ;

Mahmut, Ablajan ;

Bosse, Yohan ;

Couture, Christian ;

Page, Sylvain ;

Trahan, Sylvain ;

Boulanger, Marie-Chloe ;

Fournier, Dominique ;

Pibarot, Philippe ;

Mathieu, Patrick .

INFLAMMATION, 2013, 36 (03) :573-581

[10] Calcific aortic stenosis and its correlation with a novel inflammatory marker, the lymphocyte/monocyte ratio [J].

Efe, Tolga Han ;

Yayla, Kadriye Gayretli ;

Yayla, Cagri ;

Ertem, Ahmet Goktug ;

Cimen, Tolga ;

Pamukcu, Hilal Erken ;

Bilgin, Murat ;

Erat, Mehmet ;

Dogan, Mehmet ;

Yeter, Ekrem .

REVISTA PORTUGUESA DE CARDIOLOGIA, 2016, 35 (11) :573-578

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