A novel strategy to selectively detect Fe(III) in aqueous media driven by hydrolysis of a rhodamine 6G Schiff base

被引:248
作者
Lee, Min Hee [2 ]
Van Giap, Thang [1 ]
Kim, Sang Hoon [2 ]
Lee, Young Hoon [2 ]
Kang, Chulhun [1 ]
Kim, Jong Seung [2 ]
机构
[1] Kyung Hee Univ, Sch EW Med Sci, Yongin 446701, South Korea
[2] Korea Univ, Dept Chem, Seoul 136701, South Korea
基金
新加坡国家研究基金会;
关键词
III-AMPLIFIED FLUORESCENCE; RAT HEPATOCYTES; LABILE IRON; CHEMODOSIMETER; CHEMOSENSOR; CANCER; POOL;
D O I
10.1039/b921526c
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A rhodamine-based probe (FS1) was synthesized and its fluorescence properties and application to an iron-overloaded cell line demonstrated. FS1 underwent fluorogenic changes by the Fe3+-catalyzed reaction, even in the presence of other metal cations in vitro. Chemodosimeter FS1 demonstrated selective and sensitive detection of intracellular Fe3+ in hepatocytes.
引用
收藏
页码:1407 / 1409
页数:3
相关论文
共 21 条
[1]   On the development of sensor molecules that display FeIII-amplified fluorescence [J].
Bricks, JL ;
Kovalchuk, A ;
Trieflinger, C ;
Nofz, M ;
Büschel, M ;
Tolmachev, AI ;
Daub, J ;
Rurack, K .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (39) :13522-13529
[2]  
Dean JohnA., 1987, LANGES HDB CHEM, V13th
[3]   Fluorescence analysis of the labile iron pool of mammalian cells [J].
Epsztejn, S ;
Kakhlon, O ;
Glickstein, H ;
Breuer, W ;
Cabantchik, ZI .
ANALYTICAL BIOCHEMISTRY, 1997, 248 (01) :31-40
[4]   Redox signaling and cancer: The role of "labile" iron [J].
Galaris, Dimitrios ;
Skiada, Vasiliki ;
Barbouti, Alexandra .
CANCER LETTERS, 2008, 266 (01) :21-29
[5]   Characterisation of citrate and iron citrate uptake by cultured rat hepatocytes [J].
Graham, RM ;
Morgan, EH ;
Baker, E .
JOURNAL OF HEPATOLOGY, 1998, 29 (04) :603-613
[6]   REACTIVE OXYGEN SPECIES AND THE CENTRAL-NERVOUS-SYSTEM [J].
HALLIWELL, B .
JOURNAL OF NEUROCHEMISTRY, 1992, 59 (05) :1609-1623
[7]  
HOWARD JB, 1991, ADV PROTEIN CHEM, V42, P199
[8]  
KARSTEN E, 2005, AMINES ALIPHATIC ULL
[9]   A new trend in rhodamine-based chemosensors: application of spirolactam ring-opening to sensing ions [J].
Kim, Ha Na ;
Lee, Min Hee ;
Kim, Hyun Jung ;
Kim, Jong Seung ;
Yoon, Juyoung .
CHEMICAL SOCIETY REVIEWS, 2008, 37 (08) :1465-1472
[10]   Calixarene-derived fluorescent probes [J].
Kim, Jong Seung ;
Quang, Duong Tuan .
CHEMICAL REVIEWS, 2007, 107 (09) :3780-3799