Solubilization and deaggregation of cobalt bis(dicarbollide) derivatives in water by biocompatible excipients

被引：22
|
作者：
Rak, Jakub [1 ]
Kaplanek, Robert [1 ]
Kral, Vladimir [1 ]
机构：
[1] Inst Chem Technol, Dept Analyt Chem, CR-16628 Prague 6, Czech Republic
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 03期
关键词：
Cobalt bis(dicarbollide); Metallacarborane; Excipient; Solubilization; Deaggregation; Cyclodextrin; Surfactant; BETA-CYCLODEXTRIN; HIV PROTEASE; LIGHT-SCATTERING; BORON CLUSTERS; METALLACARBORANES; CHEMISTRY; BACTERIOCHLORIN; COMPLEXATION; INHIBITORS; CARBORANE;
D O I：
10.1016/j.bmcl.2009.12.038
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In the field of medicinal chemistry, cobalt bis(dicarbollide) derivatives are promising therapeutic agents. The potential pharmaceutical utilization of metallacarboranes is complicated due to spontaneous self-assembling in water. This problem can be solved by using suitable deaggregating agent. We present here the comprehensive screen of substituted cobalt bis(dicarbollide) derivatives with cyclodextrin derivatives, classical surfactants and amphiphilic copolymers to find general biocompatible excipients. Preliminary results are obtained by using UV/Vis spectroscopy as the technique with the best ratio of applicable information to time and source dependence. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1045 / 1048
页数：4
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