Angiotensin-converting enzyme insertion/deletion polymorphism in patients with acute and chronic pancreatitis

被引:9
作者
Hucl, Tomas [1 ]
Kylanpaa, Marja-Leena [8 ]
Kuenzli, Beat [2 ]
Witt, Heiko [4 ]
Lempinen, Marko [8 ]
Schneider, Alexander [1 ]
Kemppainen, Esko [8 ]
Lohr, Matthias [1 ]
Haas, Stephan L. [1 ]
Friess, Helmut [2 ]
Ockenga, Johann
Rosendahl, Jonas [3 ,5 ]
Schulz, Hans-Ulrich [6 ]
Gress, Thomas [7 ]
Singer, Manfred V. [1 ]
Pfuetzer, Roland H. [1 ]
机构
[1] Univ Heidelberg, Dept Med Gastroenterol Hepatol & Infect Dis 2, D-6800 Mannheim, Germany
[2] Tech Univ Munich, Dept Surg, Munich, Germany
[3] Charite, CCM, Dept Gastroenterol Hepatol & Endocrinol, D-13353 Berlin, Germany
[4] Charite, Charite Campus Virchow, Dept Gastroenterol & Hepatol, D-13353 Berlin, Germany
[5] Univ Leipzig, Dept Gastroenterol & Hepatol, Leipzig, Germany
[6] Otto von Guericke Univ, Dept Surg, Magdeburg, Germany
[7] Univ Marburg, Dept Gastroenterol, Marburg, Germany
[8] Helsinki Univ Cent Hosp, Dept Surg, Helsinki, Finland
关键词
acute pancreatitis; angiotensin-converting enzyme; chronic pancreatitis; genetic polymorphism; CYSTIC-FIBROSIS GENE; DELETION POLYMORPHISM; STELLATE CELLS; SYSTEM; CLASSIFICATION; MUTATIONS; INFLAMMATION; ENDOCRINE; INHIBITOR; DISEASE;
D O I
10.1097/MEG.0b013e328326f586
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background Reduction in angiotensin-converting enzyme (ACE) activity has been shown to attenuate pancreatic stellate cell activation and pancreatic fibrosis and suggested as a potential treatment for chronic pancreatitis. The ACE gene insertion/deletion (I/D) polymorphism in intron 16 accounts for nearly half the variation in serum ACE levels. This study determined the frequency of the I/D polymorphism in patients with acute and chronic pancreatitis. Methods In total, 887 patients (346 with alcoholic, 443 with nonalcoholic, and 98 with acute pancreatitis) were enrolled, and were compared with 1294 healthy controls. Genotyping of the I/D polymorphism was performed by PCR or melting curve analyses. Results No significant differences were found in the prevalence of the ACE-deletion genotype frequencies when patients with alcoholic (27.5%), nonalcoholic (26.4%), and acute pancreatitis (32.7%) were compared with controls (26.9%). Likewise, allele frequencies of the ACE deletion polymorphism were not significantly different in patients with alcoholic (53.8%), nonalcoholic (50.6%), and acute pancreatitis (54.1%) and controls (52.7%). Conclusion The I/D polymorphism of the ACE gene was not found to be associated with acute and chronic pancreatitis. Eur J Gastroenterol Hepatol 21: 1032-1035 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码:1032 / 1035
页数:4
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