SUMO is growing senescent

被引：31

作者：

Bischof, Oliver ^{[1
]}

Dejean, Anne ^{[1
]}

机构：

[1] Inst Pasteur, Unite Org Nucl & Oncogenese, INSERM U579, F-75724 Paris 15, France

来源：

CELL CYCLE | 2007年 / 6卷 / 06期

关键词：

senescence; tumor suppression; tumorigenesis; SUMO; chromatin; telomeres;

D O I：

10.4161/cc.6.6.4021

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cellular senescence is an irreversible cell cycle arrest that curbs unrestrained, aberrant proliferation of mammalian cells and is now recognized as a prominent tumor suppressive mechanism. We have shown recently that the E3 SUMO ligase PIASy actively contributes to execution of the senescence program, thus, providing the first evidence for a direct role of SUMO modification in this process. Here, we discuss some of the implications for this novel connection and future directions to study in more detail the importance of the SUMO pathway in senescence and tumorigenesis.

引用

页码：677 / 681

页数：5

共 39 条

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