DNA damage responses in ageing

被引：48

作者：

da Silva, Paulo F. L. ^{[1
,2
]}

Schumacher, Bjoern ^{[1
,2
]}

机构：

[1] Univ Cologne, Med Fac, Inst Genome Stabil Ageing & Dis, Joseph Stelzmann Str 26, D-50931 Cologne, Germany

[2] Univ Cologne, Ctr Mol Med Cologne CMMC, Cologne Excellence Cluster Cellular Stress Respon, Joseph Stelzmann Str 26, D-50931 Cologne, Germany

来源：

OPEN BIOLOGY | 2019年 / 9卷 / 11期

关键词：

ageing; DNA repair; cellular senescence; longevity; DNA damage response;

D O I：

10.1098/rsob.190168

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ageing appears to be a nearly universal feature of life, ranging from unicellular microorganisms to humans. Longevity depends on the maintenance of cellular functionality, and an organism's ability to respond to stress has been linked to functional maintenance and longevity. Stress response pathways might indeed become therapeutic targets of therapies aimed at extending the healthy lifespan. Various progeroid syndromes have been linked to genome instability, indicating an important causal role of DNA damage accumulation in the ageing process and the development of age-related pathologies. Recently, non-cell-autonomous mechanisms including the systemic consequences of cellular senescence have been implicated in regulating organismal ageing. We discuss here the role of cellular and systemic mechanisms of ageing and their role in ageing-associated diseases.

引用

页数：11

共 178 条

[1] A complex secretory program orchestrated by the inflammasome controls paracrine senescence [J].

Acosta, Juan Carlos ;

Banito, Ana ;

Wuestefeld, Torsten ;

Georgilis, Athena ;

Janich, Peggy ;

Morton, Jennifer P. ;

Athineos, Dimitris ;

Kang, Tae-Won ;

Lasitschka, Felix ;

Andrulis, Mindaugas ;

Pascual, Gloria ;

Morris, Kelly J. ;

Khan, Sadaf ;

Jin, Hong ;

Dharmalingam, Gopuraja ;

Snijders, Ambrosius P. ;

Carroll, Thomas ;

Capper, David ;

Pritchard, Catrin ;

Inman, Gareth J. ;

Longerich, Thomas ;

Sansom, Owen J. ;

Aznar Benitah, Salvador ;

Zender, Lars ;

Gil, Jesus .

NATURE CELL BIOLOGY, 2013, 15 (08) :978-U221

[2] Motif module map reveals enforcement of aging by continual NF-κB activity [J].

Adler, Adam S. ;

Sinha, Saurabh ;

Kawahara, Tiara L. A. ;

Zhang, Jennifer Y. ;

Segal, Eran ;

Chang, Howard Y. .

GENES & DEVELOPMENT, 2007, 21 (24) :3244-3257

[3] Regulation of C-elegans longevity by specific gustatory and olfactory neurons [J].

Alcedo, J ;

Kenyon, C .

NEURON, 2004, 41 (01) :45-55

[4] Length-independent telomere damage drives post-mitotic cardiomyocyte senescence [J].

Anderson, Rhys ;

Lagnado, Anthony ;

Maggiorani, Damien ;

Walaszczyk, Anna ;

Dookun, Emily ;

Chapman, James ;

Birch, Jodie ;

Salmonowicz, Hanna ;

Ogrodnik, Mikolaj ;

Jurk, Diana ;

Proctor, Carole ;

Correia-Melo, Clara ;

Victorelli, Stella ;

Fielder, Edward ;

Berlinguer-Palmini, Rolando ;

Owens, Andrew ;

Greaves, Laura C. ;

Kolsky, Kathy L. ;

Parini, Angelo ;

Douin-Echinard, Victorine ;

Lebrasseur, Nathan K. ;

Arthur, Helen M. ;

Tual-Chalot, Simon ;

Schafer, Marissa J. ;

Roos, Carolyn M. ;

Miller, Jordan D. ;

Robertson, Neil ;

Mann, Jelena ;

Adams, Peter D. ;

Tchkonia, Tamara ;

Kirkland, James L. ;

Mialet-Perez, Jeanne ;

Richardson, Gavin D. ;

Passos, Joao F. .

EMBO JOURNAL, 2019, 38 (05)

[5] An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria [J].

Andressoo, Jaan-Olle ;

Mitchell, James R. ;

de Wit, Jan ;

Hoogstraten, Deborah ;

Volker, Marcel ;

Toussaint, Wendy ;

Speksnijder, Ewoud ;

Beems, Rudolph B. ;

van Steeg, Harry ;

Jans, Judith ;

de Zeeuw, Chris I. ;

Jaspers, Nicolaas G. J. ;

Raams, Anja ;

Lehmann, Alan R. ;

Vermeulen, Wim ;

Hoeijmakers, Jan H. J. ;

van der Horst, Gijsbertus T. J. .

CANCER CELL, 2006, 10 (02) :121-132

[6] An Xpb Mouse Model for Combined Xeroderma Pigmentosum and Cockayne Syndrome Reveals Progeroid Features upon Further Attenuation of DNA Repair [J].

Andressoo, Jaan-Olle ;

Weeda, Geert ;

de Wit, Jan ;

Mitchell, James R. ;

Beems, Rudolf B. ;

van Steeg, Harry ;

van der Horst, Gijsbertus T. J. ;

Hoeijmakers, Jan H. .

MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (05) :1276-1290

[7] Transcription-coupled repair and premature ageing [J].

Andressoo, JO ;

Hoeijmakers, JHJ .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2005, 577 (1-2) :179-194

[8] Starvation Protects Germline Stem Cells and Extends Reproductive Longevity in C-elegans [J].

Angelo, Giana ;

Van Gilst, Marc R. .

SCIENCE, 2009, 326 (5955) :954-958

[9] Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast [J].

Aris, John P. ;

Alvers, Ashley L. ;

Ferraiuolo, Roy A. ;

Fishwick, Laura K. ;

Hanvivatpong, Amanda ;

Hu, Doreen ;

Kirlew, Christine ;

Leonard, Michael T. ;

Losin, Kyle J. ;

Marraffini, Michelle ;

Seo, Arnold Y. ;

Swanberg, Veronica ;

Westcott, Jennifer L. ;

Wood, Michael S. ;

Leeuwenburgh, Christiaan ;

Dunn, William A., Jr. .

EXPERIMENTAL GERONTOLOGY, 2013, 48 (10) :1107-1119

[10] Remarkable longevity and stress resistance of nematode PI3K-null mutants [J].

Ayyadevara, Srinivas ;

Alla, Ramani ;

Thaden, John J. ;

Reis, Robert J. Shmookler .

AGING CELL, 2008, 7 (01) :13-22

← 1 2 3 4 5 6 7 8 9 10 →