Erlenmeyer azlactone synthesis with aliphatic aldehydes under solvent-free microwave conditions

被引：24
作者：
Chandrasekhar, Sosale [1 ]
Karri, Phaneendrasai [1 ]
机构：
[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 05期
关键词：
aliphatic aldehydes; alumina; azlactones; Erlenmeyer synthesis; microwave; oxazolone; solvent-free;
D O I：
10.1016/j.tetlet.2006.11.174
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-Phenyl-5(4H)-oxazolone (azlactone) reacts with aliphatic aldehydes upon adsorption on neutral alumina and irradiation with microwaves (< 2 min). The corresponding condensation products are obtained in good yields (62-78%), indicating the satisfactory resolution of a long-standing problem plaguing the classical Erlenmeyer synthesis (poor results with aliphatic aldehydes). Plausible mechanistic reasons for the success of the procedure are discussed. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：785 / 786
页数：2
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