Specific detection of Epstein-Barr virus in inflammatory pseudotumor of the spleen in a patient with a high serum level of soluble IL-2 receptor

被引：20

作者：

Yamaguchi, M ^{[1
]}

Yamamoto, T ^{[1
]}

Tate, G ^{[1
]}

Matsumoto, T ^{[1
]}

Matsumiya, A ^{[1
]}

Kuzume, M ^{[1
]}

Sanada, Y ^{[1
]}

Kumada, K ^{[1
]}

机构：

[1] Showa Univ, Fujigaoka Hosp, Dept Surg, Aoba Ku, Yokohama, Kanagawa 2278501, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 2000年 / 35卷 / 07期

关键词：

spleen; inflammatory pseudotumor; Epstein-Barr virus; soluble interleukin-2 receptor;

D O I：

10.1007/s005350070082

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A case of inflammatory pseudotumor of the spleen is described in a 63-year-old woman who presented with an intrasplenic tumor and an elevated serum level of soluble interleukin 2 receptor (sIL-2R). Microscopic examination after removal of the spleen revealed that the tumor was composed of mixed cellular infiltrates, mainly lymphocytes and plasma cells, and spindle-cell proliferation. Epstein-Barr virus (EBV) was specifically detected in the tumor by in situ hybridization for EBV RNA. The serum level of sIL-2R level was normalized after splenectomy. EBV infection may play a role in the development of splenic inflammatory pseudotumor and the elevation of sIL-2R level.

引用

页码：563 / 566

页数：4

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