Evaluating the effects of Juglans regia L. extract on hyperglycaemia and insulin sensitivity in experimental type 2 diabetes in rat

被引：8
作者：
Uslu, Gozde Atila [1 ]
Uslu, Hamit [2 ]
机构：
[1] Kafkas Univ, Fac Vet Med, Dept Physiol, Kars, Turkey
[2] Kafkas Univ, Ataturk Vocat Sch Hlth Serv, Dept Hlth Care Serv, Kars, Turkey
来源：
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2022年 / 128卷 / 01期
关键词：
Type; 2; diabetes; Juglans regia; Adiponectin; Fibronectin type III domain-containing protein 5; CIRCULATING IRISIN; WALNUT LEAF; ANTIOXIDANT; ADIPONECTIN; RESISTANCE; JUGLONE; LEAVES; HYPOADIPONECTINEMIA; PATHOPHYSIOLOGY; STREPTOZOTOCIN;
D O I：
10.1080/13813455.2019.1668018
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Objective: The present study aimed to investigate the effects of Juglans regia (JR) extract on hyperglycaemia and insulin sensitivity. Methods: Forty rats were divided into 4 groups: Control (C), Diabetes Control (DC), Diabetes + Juglans regia (D + JR) and Diabetes + Metformin (D + M). Results: In the D + JR group, Fasting blood glucose (FBG) levels decreased from day 14 onwards. There was a significant decrease in plasma levels of Fibronectin Type III Domain Containing 5 (FNDC5) and adiponectin (ADP) in the DC group compared to the C group (p < .01, p < .001 respectively). In the D + JR group, there was a significant increase in plasma FNDC5 and ADP (p < .05), while the plasma Tumour necrosis factor-alpha (TNF-alpha) levels were decreased compared to the DC group (p < .001). Conclusions: In conclusion, the present study found that JR and its bioactive components alleviated insulin resistance by increasing ADP and FNDC5 and decreasing FBG in a rat model of streptozotocin (STZ) + nicotinamide (NAD)-induced type 2 diabetes (T2D).
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收藏
页码：121 / 125
页数：5
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