Sulfatase inhibitors for recidivist breast cancer treatment: A chemical review

被引：32

作者：

Shah, Ramanpreet ^{[1
]}

Singh, Jatinder ^{[1
]}

Singh, Dhandeep ^{[1
]}

Jaggi, Amteshwar Singh ^{[1
]}

Singh, Nirmal ^{[1
]}

机构：

[1] Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Pharmaceut Chem Res Lab, Patiala 147002, Punjab, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2016年 / 114卷

关键词：

Breast cancer; Sulfatase inhibitor's chemistry; Steroid sulfamate based inhibitors; Steroid non-sulfamate based inhibitors; Non-steroidal sulfamate based inhibitors; Non-steroidal non-sulfamate based inhibitors; VITRO BIOCHEMICAL EVALUATION; STEROID SULFATASE; ESTRONE-SULFATASE; IN-VITRO; POTENT INHIBITORS; DUAL AROMATASE; REVERSIBLE INHIBITORS; IRREVERSIBLE INHIBITOR; CELL-PROLIFERATION; DERIVATIVES;

D O I：

10.1016/j.ejmech.2016.02.054

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Steroid sulfatase (STS) plays a momentous role in the conversion of sulfated steroids, which are biologically inactive, into biologically active un-sulfated steroid hormones, which support the development and growth of a number of hormone-dependent cancers, including breast cancer. Therefore, inhibitors of STS are supposed to be potential drugs for the treatment of breast and other steroid-dependent cancers. The present review concentrates on broad chemical classification of steroid sulfatase inhibitors. The inhibitors reviewed are classified into four main categories: Steroid sulfamate based inhibitors; Steroid non-sulfamate based inhibitors; Non-steroidal sulfamate based inhibitors; Non-steroidal non-sulfamate based inhibitors. A succinct overview of current treatment of cancer, estradiol precursors, STS enzyme and its role in breast cancer is herein described. (C) 2016 Elsevier Masson SAS. All rights reserved.

引用

页码：170 / 190

页数：21

共 130 条

[31] Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 [J].

Ferlay, Jacques ;

Shin, Hai-Rim ;

Bray, Freddie ;

Forman, David ;

Mathers, Colin ;

Parkin, Donald Maxwell .

INTERNATIONAL JOURNAL OF CANCER, 2010, 127 (12) :2893-2917

[32] Novel D-ring modified steroid derivatives as potent, non-estrogenic, steroid sulfatase inhibitors with in vivo activity [J].

Fischer, DS ;

Chander, SK ;

Woo, LWL ;

Fenton, JC ;

Purohit, A ;

Reed, MJ ;

Potter, BVL .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2003, 84 (2-3) :343-349

[33] D-ring modified estrone derivatives as novel potent inhibitors of steroid sulfatase [J].

Fischer, DS ;

Woo, LWL ;

Mahon, MF ;

Purohit, A ;

Reed, MJ ;

Potter, BVL .

BIOORGANIC & MEDICINAL CHEMISTRY, 2003, 11 (08) :1685-1700

[34] A New Therapeutic Strategy against Hormone-Dependent Breast Cancer: The Preclinical Development of a Dual Aromatase and Sulfatase Inhibitor [J].

Foster, Paul A. ;

Chander, Surinder K. ;

Newman, Simon P. ;

Woo, L. W. Lawrence ;

Sutcliffe, Oliver B. ;

Bubert, Christian ;

Zhou, Dujin ;

Chen, Shiuan ;

Potter, Barry V. L. ;

Reed, Michael J. ;

Purohit, Atul .

CLINICAL CANCER RESEARCH, 2008, 14 (20) :6469-6477

[35] In vivo efficacy of STX213, a second-generation steroid sulfatase inhibitor, for hormone-dependent breast cancer therapy [J].

Foster, Paul A. ;

Newman, Simon P. ;

Chander, Surinder K. ;

Stengel, Chloe ;

Jhalli, Roma ;

Woo, Lawrence L. W. ;

Potter, Barry V. L. ;

Reed, Michael J. ;

Purohit, Atul .

CLINICAL CANCER RESEARCH, 2006, 12 (18) :5543-5549

[36] Synthesis of aryl sulfamate and phenol small peptide derivatives using a multidetachable sulfamate linker strategy [J].

Fournier, Diane ;

Breuil, Pierre-Alain ;

Poirier, Donald .

PEPTIDES FOR YOUTH: THE PROCEEDINGS OF THE 20TH AMERICAN PEPTIDE SYMPOSIUM, 2009, 611 :219-220

[37] Estradiol dimers as a new class of steroid sulfatase reversible inhibitors [J].

Fournier, Diane ;

Poirier, Donald .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (03) :693-696

[38] Sulfamoyloxy-substituted 2-phenylindoles: Antiestrogen-based inhibitors of the steroid sulfatase in human breast cancer cells [J].

Golob, T ;

Liebl, R ;

von Angerer, E .

BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (12) :3941-3953

[39] Hallmarks of Cancer: The Next Generation [J].

Hanahan, Douglas ;

Weinberg, Robert A. .

CELL, 2011, 144 (05) :646-674

[40] ALCOHOL, HEIGHT, AND ADIPOSITY IN RELATION TO ESTROGEN AND PROLACTIN LEVELS IN POSTMENOPAUSAL WOMEN [J].

HANKINSON, SE ;

WILLETT, WC ;

MANSON, JE ;

HUNTER, DJ ;

COLDITZ, GA ;

STAMPFER, MJ ;

LONGCOPE, C ;

SPEIZER, FE .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1995, 87 (17) :1297-1302

← 1 2 3 4 5 6 7 8 9 10 →