Sulfatase inhibitors for recidivist breast cancer treatment: A chemical review

被引：32

作者：

Shah, Ramanpreet ^{[1
]}

Singh, Jatinder ^{[1
]}

Singh, Dhandeep ^{[1
]}

Jaggi, Amteshwar Singh ^{[1
]}

Singh, Nirmal ^{[1
]}

机构：

[1] Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Pharmaceut Chem Res Lab, Patiala 147002, Punjab, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2016年 / 114卷

关键词：

Breast cancer; Sulfatase inhibitor's chemistry; Steroid sulfamate based inhibitors; Steroid non-sulfamate based inhibitors; Non-steroidal sulfamate based inhibitors; Non-steroidal non-sulfamate based inhibitors; VITRO BIOCHEMICAL EVALUATION; STEROID SULFATASE; ESTRONE-SULFATASE; IN-VITRO; POTENT INHIBITORS; DUAL AROMATASE; REVERSIBLE INHIBITORS; IRREVERSIBLE INHIBITOR; CELL-PROLIFERATION; DERIVATIVES;

D O I：

10.1016/j.ejmech.2016.02.054

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Steroid sulfatase (STS) plays a momentous role in the conversion of sulfated steroids, which are biologically inactive, into biologically active un-sulfated steroid hormones, which support the development and growth of a number of hormone-dependent cancers, including breast cancer. Therefore, inhibitors of STS are supposed to be potential drugs for the treatment of breast and other steroid-dependent cancers. The present review concentrates on broad chemical classification of steroid sulfatase inhibitors. The inhibitors reviewed are classified into four main categories: Steroid sulfamate based inhibitors; Steroid non-sulfamate based inhibitors; Non-steroidal sulfamate based inhibitors; Non-steroidal non-sulfamate based inhibitors. A succinct overview of current treatment of cancer, estradiol precursors, STS enzyme and its role in breast cancer is herein described. (C) 2016 Elsevier Masson SAS. All rights reserved.

引用

页码：170 / 190

页数：21

共 130 条

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