Therapeutic alternatives in the management of osteoradionecrosis of the jaws. Systematic review

被引：13

作者：

Camolesi, Gisela C., V ^{[1
]}

Ortega, Karem L. ^{[2
]}

Medina, Janaina Braga ^{[2
,3
]}

Campos, Luana ^{[4
,5
]}

Lorenzo Pouso, Alejandro, I ^{[6
]}

Gandara Vila, Pilar ^{[6
]}

Perez Sayans, Mario ^{[6
]}

机构：

[1] Univ Sao Paulo, Fdn Sci & Technol Dev Dent, Specializat Oral Maxillofacial Surg, Sao Paulo, SP, Brazil

[2] Univ Sao Paulo, Sch Dent, Dept Stomatol, Sao Paulo, SP, Brazil

[3] Mario Covas State Hosp Santo Andre, Div Dent, Sao Paulo, Brazil

[4] Univ Santo Amaro, Sch Dent, Dept Postgrad Implantol, Sao Paulo, Brazil

[5] Brazilian Canc Control Inst, Oral Med, Sao Paulo, Brazil

[6] Univ Santiago de Compostela, Fac Med & Dent, Oral Surg & Implantol Unit MedOralRes, Oral Med, Santiago De Compostela, Spain

来源：

MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL | 2021年 / 26卷 / 02期

关键词：

Osteoradionecrosis; radiotherapy bone necrosis; hyperbaric oxygen; pentoxifylline; teriparatide; low level laser therapy; HYPERBARIC-OXYGEN; RADIATION-THERAPY; HEAD; RADIOTHERAPY; FLAP; RECONSTRUCTION; QUALITY; CANCER; TERIPARATIDE; CHALLENGES;

D O I：

10.4317/medoral.24132

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Background: to systematically review the literature, comparing the healing of osteoradionecrosis (ORN) among the therapeutic alternatives: surgical, pharmacological and combined. Material and Methods: The review was organized according to the PRISMA protocol with regards to the following PICO question: patients with ORN of the jaws (P=Patient); all interventions reported (I = intervention); between all therapies (C=Comparison); healing of lesions (O=outcome). Results: Surgical treatment was the most common choice (46.3%) followed by pharmacological treatment, exclusively (25.9%) or combined (26.9%). Treatment exclusively by surgical intervention seems to be most effective option, with 51.2% of the lesions healed, OR for healing of 5.7 (CI95% 1.9-16.9, p=0.002). Only 1 case (0.9%) corresponded to low level laser therapy. Conclusions: It seems clear that early intervention with conservative surgical combined with pharmacological methods improves the prognosis of ORN.

引用

页码：E195 / E207

页数：13

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