Effect of penicillin induced epilepsy seizure on granulare cell layer of dentate gyrus in rat: A stereological study

被引：2
|
作者：
Adiguzel, E [1 ]
Akdogan, I [1 ]
Duzcan, SE [1 ]
Tufan, AC [1 ]
机构：
[1] Univ Pamukkale, Fac Med, Dept Anat, TR-20020 Kinikli, Turkey
来源：
NEUROSCIENCE RESEARCH COMMUNICATIONS | 2002年 / 31卷 / 02期
关键词：
penicillin; epileptic seizure; rat brain; dentate gyrus; stereology; optical fractionator;
D O I：
10.1002/nrc.10043
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Nonstereological methods have been the prefrence of investigators in the field of neuron counting. Development of stereological methods in biological sciences improved the reliability of neuroscientific investigations. This study was designed to investigate the effect of penicillin induced epilepsy seizure on total cell number of granulare cell layer of dentate gyrus. Optical fractionator method, one of the unbiased stereological methods, was used to estimate the total cell number. Seizure was observed and recorded in EEG 3-4 minutes after intracortical injection of 500 IU penicillin-G. Rat brains were removed one week later from penicillin-G introduction. The number of neurons in the granulare cell layer of dentate gyrus was less in the experimental group (111728 +/- 14110) compared to that in the control group (120228 +/- 16718). This difference was not statistically significant (p>0.05).
引用
收藏
页码：101 / 109
页数：9
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