Immunodominant antibody germlines in COVID-19

被引：18

作者：

Andreano, Emanuele ^{[1
]}

Rappuoli, Rino ^{[1
,2
]}

机构：

[1] Fdn Toscana Life Sci, Monoclonal Antibody Discovery Lab, Siena, Italy

[2] Imperial Coll, Fac Med, London, England

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2021年 / 218卷 / 05期

基金：

欧洲研究理事会;

关键词：

D O I：

10.1084/jem.20210281

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The neutralizing antibody response to SARS-CoV-2 is dominated by antibodies deriving from germlines IGHV3-53/IGHV3-66, which are also associated with self-reacting antibodies. Could vaccines avoid the expansion of this immunodominant response, decrease the risk of autoimmunity, and still protect against emerging SARS-CoV-2 variants?

引用

页数：2

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