Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort

被引：23

作者：

Fortner, Renee T. ^{[1
]}

Vitonis, Allison F. ^{[2
]}

Schock, Helena ^{[1
]}

Huesing, Anika ^{[1
]}

Johnson, Theron ^{[1
]}

Fichorova, Raina N. ^{[3
,4
]}

Fashemi, Titilayo ^{[4
]}

Yamamoto, Hidemi S. ^{[4
]}

Tjonneland, Anne ^{[5
]}

Hansen, Louise ^{[5
]}

Overvad, Kim ^{[6
]}

Boutron-Ruault, Marie-Christine ^{[7
,8
,9
]}

Kvaskoff, Marina ^{[7
,8
,9
]}

Severi, Gianluca ^{[7
,8
,9
,10
]}

Boeing, Heiner ^{[11
]}

Trichopoulou, Antonia ^{[12
,13
]}

Benetou, Vassiliki ^{[12
,13
]}

La Vecchia, Carlo ^{[12
,14
]}

Palli, Domenico ^{[15
]}

Sieri, Sabina ^{[16
]}

Tumino, Rosario ^{[17
]}

Matullo, Giuseppe ^{[18
]}

Mattiello, Amalia ^{[19
]}

Onland-Moret, N. Charlotte ^{[20
]}

Peeters, Petra H. ^{[20
,21
]}

Weiderpass, Elisabete ^{[22
,23
,24
,25
]}

Gram, Inger Torhild ^{[22
]}

Jareid, Mie ^{[22
]}

Ramon Quiros, J. ^{[26
]}

Duell, Eric J. ^{[27
]}

Sanchez, Maria-Jose ^{[28
,29
]}

Dolores Chirlaque, Maria ^{[30
,31
]}

Ardanaz, Eva ^{[29
,32
,33
]}

Larranaga, Nerea ^{[34
,35
,36
]}

Nodin, Bjorn ^{[37
]}

Brandstedt, Jenny ^{[37
,38
]}

Idahl, Annika ^{[39
]}

Khaw, Kay-Tee ^{[40
]}

Allen, Naomi ^{[41
,42
]}

Gunter, Marc ^{[43
]}

Johansson, Mattias ^{[43
]}

Dossus, Laure ^{[43
]}

Merritt, Melissa A. ^{[44
]}

Riboli, Elio ^{[44
]}

Cramer, Daniel W. ^{[2
,3
]}

Kaaks, Rudolf ^{[1
]}

Terry, Kathryn L. ^{[2
,3
]}

机构：

[1] German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany

[2] Brigham & Womens Hosp, Ob Gyn Epidemiol Ctr, Boston, MA USA

[3] Harvard Med Sch, Obstetr Gynecol & Reprod Biol, Boston, MA USA

[4] Brigham & Womens Hosp, Lab Genital Tract Biol, Boston, MA USA

[5] Danish Canc Soc Res Ctr, Unit Diet Genes & Environm, Copenhagen, Denmark

[6] Aarhus Univ, Dept Publ Hlth, Epidemiol Sect, Aarhus, Denmark

[7] INSERM, Ctr Res Epidemiol & Populat Hlth CESP, U1018 Nutr Hormones & Womens Hlth Team, F-94805 Villejuif, France

[8] Univ Paris Sud, UMRS 1018, F-94805 Villejuif, France

[9] Gustave Roussy, F-94805 Villejuif, France

[10] Human Genet Fdn HuGeF, Turin, Italy

[11] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[12] Hellenic Hlth Fdn, Athens, Greece

[13] Univ Athens, WHO Collaborating Ctr Nutr & Hlth, Sch Med, Dept Hyg Epidemiol & Med Stat,Unit Nutr Epidemiol, Athens, Greece

[14] Univ Milan, Dept Clin Sci & Community Hlth, I-20122 Milan, Italy

[15] Canc Res & Prevent Inst ISPO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy

[16] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[17] Civic MP Arezzo Hosp, ASP, Canc Registry & Histopathol, Ragusa, Italy

[18] Univ Torino & Human Genet Fdn HuGeF, Dept Med Sci, Turin, Italy

[19] Univ Naples Federico II, Dipartimeno Med Clin & Chirurg, Naples, Italy

[20] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands

[21] Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[22] Univ Tromso, Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[23] Inst Populat Based Canc Res, Dept Res Canc Registry Norway, Oslo, Norway

[24] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[25] Folkhalsan Res Ctr, Genet Epidemiol Grp, Helsinki, Finland

[26] Publ Hlth Directorate, Asturias, Spain

[27] Catalan Inst Oncol ICO, Bellvitge Biomed Res Inst IDIBELL, Canc Epidemiol Res Program, Barcelona, Spain

[28] Univ Granada, Hosp Univ Granada, Escuela Andaluza Salud Publ, Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain

[29] CIBERESP, Madrid, Spain

[30] Murcia Hlth Author, Dept Epidemiol, Murcia, Spain

[31] Univ Murcia, CIBERESP, IMIB Arrixaca, Murcia, Spain

[32] Navarra Publ Hlth Inst, Pamplona, Spain

[33] Navarra Publ Hlth Inst, IdiSNA, Pamplona, Spain

[34] Publ Hlth Div, San Sebastian, Spain

[35] BioDonostia Res Inst, San Sebastian, Spain

[36] CIBERESP, Basque Reg Hlth Dept, San Sebastian, Spain

[37] Lund Univ, Dept Clin Sci, Lund, Sweden

[38] Skane Univ Hosp, Div Surg, Lund, Sweden

[39] Umea Univ, Dept Clin Sci Obstet & Gynecol, S-90187 Umea, Sweden

[40] Univ Cambridge, Canc Epidemiol Unit, Cambridge, England

[41] Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England

[42] Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England

[43] Int Agcy Res Canc, Lyon, France

[44] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

来源：

JOURNAL OF OVARIAN RESEARCH | 2017年 / 10卷

基金：

瑞典研究理事会; 英国医学研究理事会;

关键词：

Ovarian cancer; Early detection markers; CA125; CA15.3; HE4; EPIDIDYMIS PROTEIN 4; TUMOR-MARKER; SERUM CA125; ANTIGEN; 125; HIGH-RISK; NORMAL-PREGNANCY; MENSTRUAL-CYCLE; WOMEN; POSTMENOPAUSAL; CA-125;

D O I：

10.1186/s13048-017-0315-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening. Methods: We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Improvements in discrimination of prediction models adjusting for correlates of the markers were evaluated among postmenopausal women in the nested case-control study (n = 590 cases). Generalized linear models were used to calculate geometric means of CA125, CA15.3, and HE4. CA72.4 above vs. below limit of detection was evaluated using logistic regression. Early detection prediction was modeled using conditional logistic regression. Results: CA125 concentrations were lower, and CA15.3 higher, in post-vs. premenopausal women (p <= 0.02). Among postmenopausal women, CA125 was higher among women with higher parity and older age at menopause (p(trend) <= 0. 02), but lower among women reporting oophorectomy, hysterectomy, ever use of estrogen-only hormone therapy, or current smoking (p < 0.01). CA15.3 concentrations were higher among heavier women and in former smokers (p <= 0.03). HE4 was higher with older age at blood collection and in current smokers, and inversely associated with OC use duration, parity, and older age at menopause (<= 0.02). No associations were observed with CA72.4. Adjusting for correlates of the markers in prediction models did not improve the discrimination. Conclusions: This study provides insights into sources of variation in ovarian cancer early detection markers in healthy women and informs about the utility of individualizing marker cutpoints based on epidemiologic factors.

引用

页码：1 / 14

页数：14

共 48 条

[1] Serum CA125 at 11-14 weeks of gestation in women with morphologically normal ovaries [J].

Aslam, N ;

Ong, C ;

Woelfer, B ;

Nicolaides, K ;

Jurkovic, D .

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2000, 107 (05) :689-690

[2] Relationships among Serum CA15-3 Tumor Marker, TNM Staging, and Estrogen and Progesterone Receptor Expression in Benign and Malignant Breast Lesions [J].

Atoum, Manar ;

Nimer, Nisreen ;

Abdeldayem, Sawsan ;

Nasr, Hamzah .

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2012, 13 (03) :857-860

[3]

Baird DT, 2001, HUM REPROD, V16, P1527

[4] Reference intervals for carcinoembryonic antigen (CEA), CA125, MUC1, Alfa-foeto-protein (AFP), neuron-specific enolase (NSE) and CA19.9 from the NORIP study [J].

Bjerner, Johan ;

Hogetveit, Anita ;

Akselberg, Katrine Wold ;

Vangsnes, Kirsti ;

Paus, Elisabeth ;

Bjoro, Trine ;

Bormer, Ole Petter ;

Nustad, Kjell .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 2008, 68 (08) :703-713

[5] Human epididymis protein 4 reference limits and natural variation in a Nordic reference population [J].

Bolstad, Nils ;

Oijordsbakken, Miriam ;

Nustad, Kjell ;

Bjerner, Johan .

TUMOR BIOLOGY, 2012, 33 (01) :141-148

[6] Serum tumor marker immunoassays in gynecologic oncology: Establishment of reference values [J].

Bon, GG ;

Kenemans, P ;

Verstraeten, R ;

vanKamp, GJ ;

Hilgers, J .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1996, 174 (01) :107-114

[7] Effect of hormone replacement therapy on serum levels of tumor markers in healthy postmenopausal women [J].

Cengiz, B ;

Atabekoglu, C ;

Cetinkaya, E ;

Cengiz, SD .

MATURITAS, 2003, 46 (04) :301-306

[8]

Crump C, 2000, CANCER EPIDEM BIOMAR, V9, P1107

[9] Endometrial protein PP14 and CA-125 in recurrent miscarriage patients; correlation with pregnancy outcome [J].

Dalton, CF ;

Laird, SM ;

Estdale, SE ;

Saravelos, HG ;

Li, TC .

HUMAN REPRODUCTION, 1998, 13 (11) :3197-3202

[10] MUC16 is produced in tracheal surface epithelium and submucosal glands and is present in secretions from normal human airway and cultured bronchial epithelial cells [J].

Davies, Julia R. ;

Kirkham, Sara ;

Svitacheva, Naila ;

Thornton, David J. ;

Carlstedt, Ingemar .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2007, 39 (10) :1943-1954

← 1 2 3 4 5 →