Is plasticity of synapses the mechanism of long-term memory storage?

被引:213
作者
Abraham, Wickliffe C. [1 ]
Jones, Owen D. [1 ]
Glanzman, David L. [2 ,3 ,4 ]
机构
[1] Univ Otago, Brain Res New Zealand, Dept Psychol, Brain Hlth Res Ctr, Box 56, Dunedin 9010, New Zealand
[2] Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90095 USA
基金
美国国家科学基金会;
关键词
D O I
10.1038/s41539-019-0048-y
中图分类号
G40 [教育学];
学科分类号
040101 ; 120403 ;
摘要
It has been 70 years since Donald Hebb published his formalized theory of synaptic adaptation during learning. Hebb's seminal work foreshadowed some of the great neuroscientific discoveries of the following decades, including the discovery of long-term potentiation and other lasting forms of synaptic plasticity, and more recently the residence of memories in synaptically connected neuronal assemblies. Our understanding of the processes underlying learning and memory has been dominated by the view that synapses are the principal site of information storage in the brain. This view has received substantial support from research in several model systems, with the vast majority of studies on the topic corroborating a role for synapses in memory storage. Yet, despite the neuroscience community's best efforts, we are still without conclusive proof that memories reside at synapses. Furthermore, an increasing number of non-synaptic mechanisms have emerged that are also capable of acting as memory substrates. In this review, we address the key findings from the synaptic plasticity literature that make these phenomena such attractive memory mechanisms. We then turn our attention to evidence that questions the reliance of memory exclusively on changes at the synapse and attempt to integrate these opposing views.
引用
收藏
页数:10
相关论文
共 129 条
  • [1] Synapse-specific representation of the identity of overlapping memory engrams
    Abdou, Kareem
    Shehata, Mohammad
    Choko, Kiriko
    Nishizono, Hirofumi
    Matsuo, Mina
    Muramatsu, Shin-ichi
    Inokuchi, Kaoru
    [J]. SCIENCE, 2018, 360 (6394) : 1227 - 1231
  • [2] Abraham W., 1991, KINDLING SYNAPTIC PL, P92
  • [3] Memory retention - the synaptic stability versus plasticity dilemma
    Abraham, WC
    Robins, A
    [J]. TRENDS IN NEUROSCIENCES, 2005, 28 (02) : 73 - 78
  • [4] Abraham WC, 2002, J NEUROSCI, V22, P9626
  • [5] Metaplasticity: The plasticity of synaptic plasticity
    Abraham, WC
    Bear, MF
    [J]. TRENDS IN NEUROSCIENCES, 1996, 19 (04) : 126 - 130
  • [6] Activity-dependent presynaptic facilitation and Hebbian LTP are both required and interact during classical conditioning in Aplysia
    Antonov, I
    Antonova, I
    Kandel, ER
    Hawkins, RD
    [J]. NEURON, 2003, 37 (01) : 135 - 147
  • [7] Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions
    Ariazi, Jennifer
    Benowitz, Andrew
    De Biasi, Vern
    Den Boer, Monique L.
    Cherqui, Stephanie
    Cui, Haifeng
    Douillet, Nathalie
    Eugenin, Eliseo A.
    Favre, David
    Goodman, Spencer
    Gousset, Karine
    Hanein, Dorit
    Israel, David I.
    Kimura, Shunsuke
    Kirkpatrick, Robert B.
    Kuhn, Nastaran
    Jeong, Claire
    Lou, Emil
    Mailliard, Robbie
    Maio, Stephen
    Okafo, George
    Osswald, Matthias
    Pasquier, Jennifer
    Polak, Roel
    Pradel, Gabriele
    de Rooij, Bob
    Schaeffer, Peter
    Skeberdis, Vytenis A.
    Smith, Ian F.
    Tanveer, Ahmad
    Volkmann, Niels
    Wu, Zhenhua
    Zurzolo, Chiara
    [J]. FRONTIERS IN MOLECULAR NEUROSCIENCE, 2017, 10
  • [8] Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons
    Ashley, James
    Cordy, Benjamin
    Lucia, Diandra
    Fradkin, Lee G.
    Budnik, Vivian
    Thomson, Travis
    [J]. CELL, 2018, 172 (1-2) : 262 - +
  • [9] Impermanence of dendritic spines in live adult CA1 hippocampus
    Attardo, Alessio
    Fitzgerald, James E.
    Schnitzer, Mark J.
    [J]. NATURE, 2015, 523 (7562) : 592 - +
  • [10] Dynamic DNA methylation: a prime candidate for genomic metaplasticity and behavioral adaptation
    Baker-Andresen, Danay
    Ratnu, Vikram S.
    Bredy, Timothy W.
    [J]. TRENDS IN NEUROSCIENCES, 2013, 36 (01) : 3 - 13