Effects of L-/N-Type Calcium Channel Blockers on Angiotensin II-Renin Feedback in Hypertensive Patients

被引：4

作者：

Kawabata, Yutaka ^{[1
]}

Soeki, Takeshi ^{[1
]}

Ito, Hiroyuki ^{[1
]}

Matsuura, Tomomi ^{[1
]}

Kusunose, Kenya ^{[1
]}

Ise, Takayuki ^{[1
]}

Yamaguchi, Koji ^{[1
]}

Tobiume, Takeshi ^{[1
]}

Yagi, Shusuke ^{[1
]}

Fukuda, Daiju ^{[2
]}

Yamada, Hirotsugu ^{[3
]}

Wakatsuki, Tetsuzo ^{[1
]}

Kitani, Mitsuhiro ^{[4
]}

Kawano, Kazuhiro ^{[5
]}

Taketani, Yoshio ^{[6
]}

Sata, Masataka ^{[1
]}

机构：

[1] Tokushima Univ, Dept Cardiovasc Med, Grad Sch Biomed Sci, Tokushima, Japan

[2] Tokushima Univ, Grad Sch Biomed Sci, Dept Cardiodiabet Med, Tokushima, Japan

[3] Tokushima Univ, Grad Sch Biomed Sci, Dept Community Med Cardiol, Tokushima, Japan

[4] Kagawa Prefectural Shirotori Hosp, Dept Cardiovasc Med, Higashikagawa, Japan

[5] Yoshinogawa Med Ctr, Dept Cardiovasc Med, Yoshinogawa, Japan

[6] Shikoku Med Ctr Children & Adults, Dept Cardiovasc Med, Zentsuji, Japan

来源：

INTERNATIONAL JOURNAL OF HYPERTENSION | 2020年 / 2020卷

关键词：

L/N-TYPE; BLOOD-PRESSURE; ALDOSTERONE SYSTEM; NADPH OXIDASE; HEART-RATE; CILNIDIPINE; ACTIVATION; NISOLDIPINE; PROTEINURIA; DYSFUNCTION;

D O I：

10.1155/2020/6653851

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives. Cilnidipine, an L-/N-type calcium channel blocker (CCB), has unique organ-protective properties due to suppression of hyperactivity in the sympathetic nervous system and renin-angiotensin system (RAS). In this study, we hypothesized that cilnidipine might exert a renoprotective effect by suppressing the RAS. Methods. A total of 25 hypertensive patients receiving a RAS inhibitor were randomly assigned to a cilnidipine (n = 12) or amlodipine (n = 13) group. The effects of cilnidipine on proteinuria and angiotensin II-renin feedback were assessed. Results. After 6 months of treatment, both systolic and diastolic blood pressures were significantly reduced to a similar extent in both groups. The urine albumin-to-creatinine ratio was significantly lower in the cilnidipine group (p<0.05) than in the amlodipine group. Amlodipine increased plasma angiotensin I and angiotensin II levels (p<0.05), whereas cilnidipine did not. Interestingly, the cilnidipine group had a higher ratio of angiotensin-(1-7) (Ang-(1-7)) to angiotensin II in plasma than the amlodipine group (p<0.05). Conclusions. The L-/N-type CCB cilnidipine, but not amlodipine, decreased urinary albumin excretion in hypertensive patients. Cilnidipine also increased the ratio of Ang-(1-7) to angiotensin II in plasma, which might be one factor underlying its beneficial effects.

引用

页数：7

共 27 条

[21] Long-term blockade of L/N-type Ca2+channels by cilnidipine ameliorates repolarization abnormality of the canine hypertrophied heart [J].