Phenyltrimethylammonium Salts as Methylation Reagents in the Nickel-Catalyzed Methylation of C-H Bonds

被引：120

作者：

Uemura, Takeshi ^{[1
]}

Yamaguchi, Mao ^{[1
]}

Chatani, Naoto ^{[1
]}

机构：

[1] Osaka Univ, Fac Engn, Dept Appl Chem, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 09期

基金：

日本科学技术振兴机构;

关键词：

C-H activation; chelation assistance; methylation; nickel; phenyltrimethylammonium iodide; ARYLTRIMETHYLAMMONIUM IODIDES; ARYLZINC REAGENTS; C(SP(3))-H BONDS; DIRECTING GROUPS; CROSS-COUPLINGS; AMMONIUM-SALTS; ALKYL-HALIDES; FUNCTIONALIZATION; ACTIVATION; ARYLATION;

D O I：

10.1002/anie.201511197

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Methylation of C(sp(2))-H bonds was achieved through the Ni-II-catalyzed reaction of benzamides with phenyltrimethylammonium bromide or iodide as the source of the methyl group. The reaction has a broad scope and shows high functional-group compatibility. The reaction is also applicable to the methylation of C(sp(3))-H bonds in aliphatic amides.

引用

页码：3162 / 3165

页数：4

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