Heterotrimeric G proteins control stem cell proliferation through CLAVATA signaling in Arabidopsis

被引：97

作者：

Ishida, Takashi ^{[1
]}

Tabata, Ryo ^{[1
]}

Yamada, Masashi ^{[2
,3
,4
]}

Aida, Mitsuhiro ^{[5
]}

Mitsumasu, Kanako ^{[1
]}

Fujiwara, Masayuki ^{[5
]}

Yamaguchi, Katsushi ^{[5
,6
]}

Shigenobu, Shuji ^{[6
]}

Higuchi, Masayuki ^{[5
]}

Tsuji, Hiroyuki ^{[5
]}

Shimamoto, Ko ^{[5
]}

Hasebe, Mitsuyasu ^{[7
,8
]}

Fukuda, Hiroo ^{[2
]}

Sawa, Shinichiro ^{[1
]}

机构：

[1] Kumamoto Univ, Grad Sch Sci & Technol, Kumamoto, Japan

[2] Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo 113, Japan

[3] Duke Univ, Dept Biol, Durham, NC USA

[4] Duke Univ, Inst Genome Sci & Policy, Ctr Syst Biol, Durham, NC USA

[5] Nara Inst Sci & Technol, Grad Sch Biol Sci, Ikoma, Japan

[6] Natl Inst Basic Biol, Funct Genom Facil, Okazaki, Aichi 444, Japan

[7] Natl Inst Basic Biol, Div Evolutionary Biol, Okazaki, Aichi 444, Japan

[8] Grad Univ Adv Studies, Sch Life Sci, Okazaki, Aichi, Japan

来源：

EMBO REPORTS | 2014年 / 15卷 / 11期

关键词：

Arabidopsis thaliana; heterotrimeric G protein; peptide hormone; RECEPTOR-LIKE PROTEIN KINASE 2; stem cell homeostasis; RECEPTOR-LIKE KINASE; BETA-SUBUNIT; G-ALPHA; SHOOT; MERISTEM; REGULATOR; THALIANA; DIVISION; ROLES; GAMMA;

D O I：

10.15252/embr.201438660

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell-to-cell communication is a fundamental mechanism for coordinating developmental and physiological events in multicellular organisms. Heterotrimeric G proteins are key molecules that transmit extracellular signals; similarly, CLAVATA signaling is a crucial regulator in plant development. Here, we show that Arabidopsis thaliana G mutants exhibit an enlarged stem cell region, which is similar to that of clavata mutants. Our genetic and cell biological analyses suggest that the G protein beta-subunit1 AGB1 and RPK2, one of the major CLV3 peptide hormone receptors, work synergistically in stem cell homeostasis through their physical interactions. We propose that AGB1 and RPK2 compose a signaling module to facilitate meristem development.

引用

页码：1202 / 1209

页数：8

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