Facile and Clean Synthesis of Furopyridine Derivatives via Three-Component Reaction in Aqueous Media Without Catalyst

被引：10

作者：

Shi, Da-Qing ^{[1
]}

Yao, Hao ^{[2
]}

机构：

[1] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

[2] Xuzhou Normal Univ, Coll Chem & Chem Engn, Xuzhou, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2009年 / 39卷 / 14期

关键词：

Aqueous media; furo[2'1':5,6]pyrido[2,3-d]pyrimidine; synthesis; three-component reaction; ORGANIC-REACTIONS; FOCUS;

D O I：

10.1080/00397910802656034

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of furo[2',1':5,6]pyrido[2,3-d]pyrimidine derivatives were synthesized via the three-component reaction of an aldehyde, tetronic acid, and 6-amino-1,3-dimethyl-pyrimidine-2,4-dione in aqueous media without the use of catalyst. This protocol has the advantages of better yields, less cost, reduced environmental impact, and convenient procedure.

引用

页码：2481 / 2491

页数：11

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