PSMA Expression in Tumor Neovasculature Endothelial Cells of Follicular Thyroid Adenoma as Identified by Molecular Imaging Using 68Ga-PSMA Ligand PET/CT

被引：38

作者：

Derlin, Thorsten ^{[1
]}

Kreipe, Hans-Heinrich ^{[2
]}

Schumacher, Udo ^{[3
]}

Soudah, Bisharah ^{[2
]}

机构：

[1] Hannover Med Sch, Dept Nucl Med, Carl Neuberg Str 1, D-30625 Hannover, Germany

[2] Hannover Med Sch, Inst Pathol, Hannover, Germany

[3] Univ Med Ctr Hamburg Eppendorf, Dept Anat & Expt Morphol, Hamburg, Germany

来源：

CLINICAL NUCLEAR MEDICINE | 2017年 / 42卷 / 03期

关键词：

thyroid; adenoma; cancer; neovasculature; PSMA; PET/CT; PROSTATE-CANCER; CARCINOMA; GLAND;

D O I：

10.1097/RLU.0000000000001487

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The prostate-specific membrane antigen (PSMA) is expressed by both prostate cancer and other neoplasms. We report the case of a 65-year-old man with castration-resistant metastatic prostate cancer who underwent Ga-68-PSMA ligand PET/CT for restaging of disease. Ga-68-PSMA ligand accumulation was noted in a thyroid lesion, suspicious for thyroid malignancy on complementary ultrasound. Subsequent resection and histopathological analysis showed follicular thyroid adenoma with PSMA expression in tumor neovasculature endothelial cells, but not in thyroid epithelial cells. It is important to be aware that both malignant and benign thyroid neoplasms may show PSMA expression to avoid misinterpretation.

引用

页码：E173 / E174

页数：2

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