Isolation, Characterization, and Quantification of a New Anticancer Constituent from Leaves of Nyctanthes arbor-tristis

被引：2

作者：

Grover, P. ^{[1
]}

Kaur, J. ^{[2
]}

Suri, K. A. ^{[3
]}

Kumar, R. ^{[4
]}

Bansal, G. ^{[2
]}

机构：

[1] KIET Grp Inst, KIET Sch Pharm, Delhi NCR, Ghaziabad 201206, India

[2] Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala 147002, Punjab, India

[3] Indian Inst Integrat Med, Jammu 180001, Jammu & Kashmir, India

[4] Cent Univ Punjab, Sch Basic & Appl Sci, Ctr Pharmaceut Sci & Nat Prod, Bathinda 151001, India

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2022年 / 58卷 / 02期

关键词：

Nyctanthes arbor-tristis; extraction; fractionation; isolation; spectroscopy; HPLC; anticancer;

D O I：

10.1007/s10600-022-03639-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new compound, 1,1,2-tris(2 ',4 '-di-tert-butylphenyl)-4,4-dimethylpent-1-ene, was isolated and characterized from the leaves of Nyctanthes arbor-tristis L. The plant was subjected to bioactivity-guided fractionation, and a compound was isolated from chloroform extract that was found to have potent anticancer activity. The chloroform extract was further fractionated, and a pure compound was isolated that was found to be active against three cancer cell lines (HL-60, HCT-116, and A-549). An RP-HPLC method was developed for quantification of the isolated compound. The content of the isolated compound was 0.88% in the chloroform extract and 0.08% in N. arbor-tristis leaves.

引用

页码：193 / 198

页数：6

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