Neuroinflammation pathways: a general review

被引：458

作者：

Shabab, Tara ^{[1
]}

Khanabdali, Ramin ^{[2
,3
]}

Moghadamtousi, Soheil Zorofchian ^{[1
]}

Kadir, Habsah Abdul ^{[1
]}

Mohan, Gokula ^{[1
]}

机构：

[1] Univ Malaya, Inst Biol Sci, Biomol Res Grp, Biochem Program,Fac Sci, Kuala Lumpur 50603, Malaysia

[2] Univ Melbourne, Royal Womens Hosp, Dept Obstet & Gynaecol, Parkville, Vic, Australia

[3] Royal Womens Hosp, Dept Perinatal Med, Pregnancy Res Ctr, Parkville, Vic, Australia

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2017年 / 127卷 / 07期

关键词：

neuroinflammation; NF-B pathway; microglia; neuroinflammatory diseases; NF-KAPPA-B; ACTIVATED PROTEIN-KINASES; TOLL-LIKE RECEPTORS; INFLAMMATORY RESPONSES; CELL-DEATH; EXPRESSION; BRAIN; MECHANISMS; INDUCTION; MICROGLIA;

D O I：

10.1080/00207454.2016.1212854

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Activated microglial cells play an important role in immune and inflammatory responses in central nervous system and neurodegenerative diseases. Many pro-apoptotic pathways are mediated by signaling molecules that are produced during neuroinflammation. In glial cells, NF-B, a transcription factor, initiates and regulates the expression of several inflammatory processes during inflammation which are attributed to the pathology of the several neurodegenerative diseases. In this review, we discuss the most important neuroinflammatory mediators with their pathways. Attenuating cytokines production and controlling microglial inflammatory response, which are the result of understanding neuroinflammation pathways, are considered therapeutic strategies for treating neurodegenerative diseases with an inflammatory component.

引用

页码：624 / 633

页数：10

共 54 条

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