Hedgehog signalling

被引：181

作者：

Lee, Raymond Teck Ho ^{[1
]}

Zhao, Zhonghua ^{[2
]}

Ingham, Philip W. ^{[1
,2
,3
]}

机构：

[1] ASTAR, Dev & Biomed Genet Lab, Inst Mol & Cell Biol, Singapore 138673, Singapore

[2] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 636921, Singapore

[3] Univ London Imperial Coll Sci Technol & Med, Dept Med, London SW7 2AZ, England

来源：

DEVELOPMENT | 2016年 / 143卷 / 03期

关键词：

Drosophila; Hedgehog signalling; Vertebrate; PROTEIN-KINASE-A; SONIC HEDGEHOG; HEPARAN-SULFATE; PRIMARY CILIUM; PATHWAY; SHH; PHOSPHORYLATION; MECHANISMS; SUPPRESSOR; TRANSPORT;

D O I：

10.1242/dev.120154

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic target. Interest in Hh signalling thus extends across many fields, from evo-devo to cancer research and regenerative medicine. Here, and in the accompanying poster, we provide an outline of the current understanding of Hh signalling mechanisms, highlighting the similarities and differences between species.

引用

页码：367 / 372

页数：6

共 56 条

[1] Overlapping Roles and Collective Requirement for the Coreceptors GAS1, CDO, and BOC in SHH Pathway Function [J].

Allen, Benjamin L. ;

Song, Jane Y. ;

Izzi, Luisa ;

Althaus, Irene W. ;

Kang, Jong-Sun ;

Charron, Frederic ;

Krauss, Robert S. ;

McMahon, Andrew P. .

DEVELOPMENTAL CELL, 2011, 20 (06) :775-787

[2] Interactions between Hedgehog proteins and their binding partners come into view [J].

Beachy, Philip A. ;

Hymowitz, Sarah G. ;

Lazarus, Robert A. ;

Leahy, Daniel J. ;

Siebold, Christian .

GENES & DEVELOPMENT, 2010, 24 (18) :2001-2012

[3]

Bellusci S, 1997, DEVELOPMENT, V124, P53

[4] NONCANONICAL HEDGEHOG SIGNALING [J].

Brennan, Donna ;

Chen, Xiaole ;

Cheng, Lan ;

Mahoney, My ;

Riobo, Natalia A. .

VITAMINS AND HORMONES: HEDGEHOG SIGNALING, 2012, 88 :55-72

[5] The mechanisms of Hedgehog signalling and its roles in development and disease [J].

Briscoe, James ;

Therond, Pascal P. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2013, 14 (07) :416-429

[6] Mice deficient in the Fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development [J].

Chen, MH ;

Gao, N ;

Kawakami, T ;

Chuang, PT .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (16) :7042-7053

[7] Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex [J].

Cheng, SY ;

Bishop, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (08) :5442-5447

[8] Endocytosis of Hedgehog through Dispatched Regulates Long-Range Signaling [J].

D'Angelo, Gisela ;

Matusek, Tamas ;

Pizette, Sandrine ;

Therond, Pascal P. .

DEVELOPMENTAL CELL, 2015, 32 (03) :290-303

[9] Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network [J].

Dessaud, Eric ;

McMahon, Andrew P. ;

Briscoe, James .

DEVELOPMENT, 2008, 135 (15) :2489-2503

[10] The primary cilium: a signalling centre during vertebrate development [J].

Goetz, Sarah C. ;

Anderson, Kathryn V. .

NATURE REVIEWS GENETICS, 2010, 11 (05) :331-344

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