Antibiotic stress induces genetic transformability in the human pathogen Streptococcus pneumoniae

被引：336
作者：
Prudhomme, Marc [1 ]
Attaiech, Laetitia [1 ]
Sanchez, Guillaume [1 ]
Martin, Bernard [1 ]
Claverys, Jean-Pierre [1 ]
机构：
[1] Univ Toulouse 3, CNRS, UMR 5100, Lab Microbiol & Genet Mol, F-31062 Toulouse 9, France
来源：
SCIENCE | 2006年 / 313卷 / 5783期
关键词：
D O I：
10.1126/science.1127912
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Natural transformation is a widespread mechanism for genetic exchange in bacteria. Aminoglycoside and fluoroquinolone antibiotics, as well as mitomycin C, a DNA-damaging agent, induced transformation in Streptococcus pneumoniae. This induction required an intact competence regulatory cascade. Furthermore, mitomycin C induction of recA was strictly dependent on the development of competence. In response to antibiotic stress, S. pneumoniae, which lacks an SOS-like system, exhibited genetic transformation. The design of antibiotherapy should take into consideration this potential of a major human pathogen to increase its rate of genetic exchange in response to antibiotics.
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收藏
页码：89 / 92
页数：4
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