Cytokines related to MMP-11 expression by inflammatory cells and breast cancer metastasis

被引：41

作者：

Eiro, Noemi ^{[1
]}

Fernandez-Garcia, Belen ^{[1
]}

Gonzalez, Luis O. ^{[1
]}

Vizoso, Francisco J. ^{[1
]}

机构：

[1] Fdn Hosp Jove, Unidad Invest, Gijon, Asturias, Spain

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 05期

关键词：

inflammation; interleukins; matrix metalloprotease 11; metastasis; MATRIX METALLOPROTEINASES; MICROENVIRONMENT; FIBROBLASTS; INHIBITORS;

D O I：

10.4161/onci.24010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast tumors infiltrated by matrix metalloprotease 11 (MMP-11)(+) mononuclear inflammatory cells are prone to form metastases; express high levels of interleukin (IL)-1, IL-5, IL-6, IL-17, interferon beta (IFN beta) and NF kappa B; and exhibit an increased CD68(+)/(CD3(+)CD20(+)) cell ratio at their invasive front. These factors, which are implicated in the crosstalk between tumors and their inflammatory microenvironment, may emerge as attractive prognostic factors and therapeutic targets.

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页数：3

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