Cytokines related to MMP-11 expression by inflammatory cells and breast cancer metastasis

被引：41
作者：
Eiro, Noemi [1 ]
Fernandez-Garcia, Belen [1 ]
Gonzalez, Luis O. [1 ]
Vizoso, Francisco J. [1 ]
机构：
[1] Fdn Hosp Jove, Unidad Invest, Gijon, Asturias, Spain
来源：
ONCOIMMUNOLOGY | 2013年 / 2卷 / 05期
关键词：
inflammation; interleukins; matrix metalloprotease 11; metastasis; MATRIX METALLOPROTEINASES; MICROENVIRONMENT; FIBROBLASTS; INHIBITORS;
D O I：
10.4161/onci.24010
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Breast tumors infiltrated by matrix metalloprotease 11 (MMP-11)(+) mononuclear inflammatory cells are prone to form metastases; express high levels of interleukin (IL)-1, IL-5, IL-6, IL-17, interferon beta (IFN beta) and NF kappa B; and exhibit an increased CD68(+)/(CD3(+)CD20(+)) cell ratio at their invasive front. These factors, which are implicated in the crosstalk between tumors and their inflammatory microenvironment, may emerge as attractive prognostic factors and therapeutic targets.
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  • [1] Comparative analysis and clinical value of the expression of metalloproteases and their inhibitors by intratumor stromal fibroblasts and those at the invasive front of breast carcinomas
    Del Casar, J. M.
    Gonzalez, L. O.
    Alvarez, E.
    Junquera, S.
    Marin, L.
    Gonzalez, L.
    Bongera, M.
    Vazquez, J.
    Vizoso, F. J.
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2009, 116 (01) : 39 - 52
  • [2] New functions for the matrix metalloproteinases in cancer progression
    Egeblad, M
    Werb, Z
    [J]. NATURE REVIEWS CANCER, 2002, 2 (03) : 161 - 174
  • [3] Impact of CD68/(CD3+CD20) Ratio at the Invasive Front of Primary Tumors on Distant Metastasis Development in Breast Cancer
    Eiro, Noemi
    Pidal, Ivan
    Fernandez-Garcia, Belen
    Junquera, Sara
    Lamelas, Maria L.
    del Casar, Jose M.
    Gonzalez, Luis O.
    Lopez-Muniz, Alfonso
    Vizoso, Francisco J.
    [J]. PLOS ONE, 2012, 7 (12):
  • [4] Relationship between the Inflammatory Molecular Profile of Breast Carcinomas and Distant Metastasis Development
    Eiro, Noemi
    Gonzalez, Lucia
    Gonzalez, Luis O.
    Fernandez-Garcia, Belen
    Luz Lamelas, Maria
    Marin, Laura
    Gonzalez-Reyes, Salome
    Manuel del Casar, Jose
    Vizoso, Francisco J.
    [J]. PLOS ONE, 2012, 7 (11):
  • [5] Overexpression of matrix metalloproteinases and their inhibitors in mononuclear inflammatory cells in breast cancer correlates with metastasis-relapse
    Gonzalez, L. O.
    Pidal, I.
    Junquera, S.
    Corte, M. D.
    Vazquez, J.
    Rodriguez, J. C.
    Lamelas, M. L.
    Merino, A. M.
    Garcia-Muniz, J. L.
    Vizoso, F. J.
    [J]. BRITISH JOURNAL OF CANCER, 2007, 97 (07) : 957 - 963
  • [6] Immunity, Inflammation, and Cancer
    Grivennikov, Sergei I.
    Greten, Florian R.
    Karin, Michael
    [J]. CELL, 2010, 140 (06) : 883 - 899
  • [7] Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
    Hanahan, Douglas
    Coussens, Lisa M.
    [J]. CANCER CELL, 2012, 21 (03) : 309 - 322
  • [8] Cancer Associated Fibroblasts Promote Tumor Growth and Metastasis by Modulating the Tumor Immune Microenvironment in a 4T1 Murine Breast Cancer Model
    Liao, Debbie
    Luo, Yunping
    Markowitz, Dorothy
    Xiang, Rong
    Reisfeld, Ralph A.
    [J]. PLOS ONE, 2009, 4 (11):
  • [9] Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes
    Qiu, Zheng
    Dillen, Chris
    Hu, Jialiang
    Verbeke, Hannelien
    Struyf, Sofie
    Van Damme, Jo
    Opdenakker, Ghislain
    [J]. IMMUNOBIOLOGY, 2009, 214 (9-10) : 835 - 842
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