Novel pyran derivatives: Crystal structures and inhibiting human cervical cancer cells evaluation

被引：1
作者：
Lv, Guang [1 ]
Li, Wen-Jun [2 ]
Chen, Wei-Yong [3 ]
Xia, Ying [4 ]
机构：
[1] Inner Mongolia Univ Nationalities, Tongliao, Inner Mongolia, Peoples R China
[2] Chengdu Tumor Hosp, Dept Obstet & Gynecol, Chengdu, Sichuan, Peoples R China
[3] Chengdu Tumor Hosp, Dept Respirat, Chengdu, Sichuan, Peoples R China
[4] Chongqing Med & Pharmaceut Coll, Chongqing Engn Res Ctr Pharmaceut Sci, Chongqing, Peoples R China
来源：
MAIN GROUP CHEMISTRY | 2019年 / 18卷 / 03期
关键词：
Pyran; X-ray; giloma; molecular docking; TETRAHYDROISOQUINOLINE DERIVATIVES; CYCLOOXYGENASE-2; COMPLEXES;
D O I：
10.3233/MGC-180749
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Four novel pyran derivatives (1-4) were successfully prepared and realized by means of IR, H-1 NMR, HRMS and single crystal X-ray crystallography. The anticancer activity of the four compounds were investigated against four human cervical cancer cells (Hela, C-33A, B01022 and C4-1) by MTT assay. Furthermore, molecular docking studies supported the biological assay data and suggested that 2 may be a potential anticancer agent.
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收藏
页码：247 / 254
页数：8
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