Facial nerve venous malformation: A radiologic and histopathologic review of 11 cases

被引:10
作者
Guerin, Julie B. [1 ]
Takahashi, Edwin A. [1 ]
Lane, John, I [1 ]
Hoxworth, Joseph M. [2 ]
Weindling, Steven M. [3 ]
Blessing, Melissa M. [4 ]
Jentoft, Mark E. [5 ]
Carlson, Matthew L. [6 ]
Neff, Brian A. [6 ]
Wood, Christopher P. [1 ]
机构
[1] Mayo Clin, Dept Radiol, 200 First St SW, Rochester, MN 55905 USA
[2] Mayo Clin Hosp, Dept Radiol, Phoenix, AZ USA
[3] Mayo Clin, Dept Radiol, Jacksonville, FL 32224 USA
[4] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
[5] Mayo Clin, Dept Lab Med & Pathol, Jacksonville, FL 32224 USA
[6] Mayo Clin, Dept Otorhinolaryngol Head & Neck Surg, Rochester, MN 55905 USA
关键词
Facial nerve; geniculate hemangioma; temporal bone; venous malformation; VASCULAR MALFORMATIONS; INTERNATIONAL SOCIETY; TEMPORAL BONE; HEMANGIOMAS; CLASSIFICATION; TUMORS; MANAGEMENT; ANOMALIES; LESIONS;
D O I
10.1002/lio2.267
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Objective The purpose of this article was to provide a combined pathologic and radiologic review of previous pathologically diagnosed facial nerve "hemangiomas" to confirm that these lesions are most characteristic of venous malformations rather than neoplasms. Study Design Retrospective radiologic, clinical, and histopathologic review of all patients with a previous pathologically diagnosed facial nerve hemangioma of the temporal bone who underwent computed tomography or magnetic resonance imaging (MRI) were included. A consensus radiologic review for characteristic features and pathologic analysis was performed. Materials and Methods A panel of 4 neuroradiologists retrospectively analyzed CT and MRI exams for 11 facial nerve hemangiomas and provided a consensus agreement on the characteristic imaging features. Concurrently, two neuropathologists reevaluated archived tissue specimens from these lesions and applied additional immunohistochemical and histochemical stains including D240, CD31, smooth muscle actin (SMA), Verhoeff Van Gieson (VVG) and glucose transporter 1 (GLUT1). Results Lesions were composed of dilated vascular spaces with a simple, CD31-positive endothelial lining and a smooth muscle component. All lesions were negative for markers found in arterial and lymphatic malformations and infantile hemangiomas. They had characteristic radiologic features previously ascribed to facial nerve hemangiomas. Namely, these lesions are typically T1 isointense or hypointense and T2 hyperintense relative to cerebral cortex and heterogeneously enhance on MRI. Bony canal expansion and erosion, intralesional calcification, and intracranial extension are common. Conclusions On the basis of this radiologic and pathologic review, these lesions are best characterized as venous malformations. Level of Evidence 4
引用
收藏
页码:347 / 352
页数:6
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