Modeling the Phenotypic Architecture of Autism Symptoms from Time of Diagnosis to Age 6

被引：22

作者：

Georgiades, Stelios ^{[1
]}

Boyle, Michael ^{[1
]}

Szatmari, Peter ^{[2
]}

Hanna, Steven ^{[1
]}

Duku, Eric ^{[1
]}

Zwaigenbaum, Lonnie ^{[3
]}

Bryson, Susan ^{[4
]}

Fombonne, Eric ^{[5
]}

Volden, Joanne ^{[3
]}

Mirenda, Pat ^{[6
]}

Smith, Isabel ^{[4
]}

Roberts, Wendy ^{[7
]}

Vaillancourt, Tracy ^{[8
]}

Waddell, Charlotte ^{[9
]}

Bennett, Teresa ^{[1
]}

Elsabbagh, Mayada ^{[5
]}

Thompson, Ann ^{[1
]}

机构：

[1] McMaster Univ, Offord Ctr Child Studies, Hamilton, ON L8S 4L8, Canada

[2] Univ Toronto, Hosp Sick Children, Ctr Addict & Mental Hlth, Toronto, ON M5G 1X8, Canada

[3] Univ Alberta, Edmonton, AB, Canada

[4] Dalhousie Univ, IWK Hlth Ctr, Halifax, NS, Canada

[5] McGill Univ, Montreal, PQ, Canada

[6] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada

[7] Univ Toronto, Toronto, ON, Canada

[8] Univ Ottawa, Ottawa, ON, Canada

[9] Simon Fraser Univ, Vancouver, BC, Canada

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2014年 / 44卷 / 12期

基金：

加拿大健康研究院;

关键词：

Autism symptoms; Classification; Phenotypic heterogeneity; SPECTRUM DISORDERS; DSM-5; CRITERIA; HETEROGENEITY; CLASSIFICATION; BEHAVIOR; CHILDREN;

D O I：

10.1007/s10803-014-2167-x

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

The latent class structure of autism symptoms from the time of diagnosis to age 6 years was examined in a sample of 280 children with autism spectrum disorder. Factor mixture modeling was performed on 26 algorithm items from the Autism Diagnostic Interview - Revised at diagnosis (Time 1) and again at age 6 (Time 2). At Time 1, a "2-factor/3-class" model provided the best fit to the data. At Time 2, a "2-factor/2-class" model provided the best fit to the data. Longitudinal (repeated measures) analysis of variance showed that the "2-factor/3-class" model derived at the time of diagnosis allows for the identification of a subgroup of children (9 % of sample) who exhibit notable reduction in symptom severity.

引用

页码：3045 / 3055

页数：11

共 31 条

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