Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma

被引：17

作者：

Gao, Xiaoxv ^{[1
]}

Sun, Chengpeng ^{[1
]}

Yu, Zhenglong ^{[1
]}

Cang, Jian ^{[1
]}

Tian, Xiangge ^{[1
]}

Huo, Xiaokui ^{[1
]}

Feng, Lei ^{[1
]}

Liu, Xinguang ^{[1
]}

Wang, Chao ^{[1
]}

Zhang, Baojing ^{[1
]}

Ma, Xiaochi ^{[1
]}

机构：

[1] Dalian Med Univ, Acad Integrat Med, Dept Biochem & Mol Biol, Coll Pharm, Dalian 116044, Peoples R China

来源：

ACTA PHARMACEUTICA SINICA B | 2018年 / 8卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Alismatis Rhizoma; Qualitative analysis; Saccharide; Terpene; Lipase; MONOSACCHARIDE COMPOSITION; LIQUID; TRITERPENOIDS;

D O I：

10.1016/j.apsb.2017.09.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In order to clarify regions of production and to discriminate processing methods, quantitative and qualitative analyses for saccharides and terpenes in 35 batches of Alismatis Rhizoma were performed. Methodologies included HPLC-PDA, HPLC-VWD and UHPLC-MSn, combined with principal component analysis (PCA) and partial least squares regression techniques (PLSR). The inhibitory effects of triterpenes and Alismatis Rhizoma extracts on lipase activity were evaluated in vitro. PLSR analysis revealed significant positive correlations (R-2 = 0.5795) between the contents of triterpenes 10, 14, 15, 18 and 22 and the inhibitory effects of Alismatis Rhizoma. The present study establishes an effective method for simultaneous determination of multiple components, and identifies key bioactive triterpenes. These results can be used for systematic and novel analytical strategies for the quality control of Alismatis Rhizoma production. (C) 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

引用

页码：242 / 251

页数：10

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[2]

[Anonymous], ACTA PHARM SIN B

[3]

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