No association of the LRRK2 genetic variants with Alzheimer's disease in Han Chinese individuals

被引：22

作者：

Bi, Rui ^{[1
,2
,3
]}

Zhao, Liansheng ^{[4
,5
,6
]}

Zhang, Chen ^{[7
]}

Lu, Weihong

Feng, Jia-Qi ^{[1
,2
]}

Wang, Yingcheng ^{[4
,5
,6
]}

Ni, Jianliang ^{[8
]}

Zhang, Jiangtao ^{[8
]}

Li, Guo-Dong ^{[1
,2
,9
]}

Hu, Qiu-Xiang ^{[1
,2
,3
]}

Wang, Dong ^{[1
,2
]}

Yao, Yong-Gang ^{[1
,2
]}

Li, Tao ^{[4
,5
,6
]}

机构：

[1] Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China

[2] Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China

[3] Univ Chinese Acad Sci, Beijing, Peoples R China

[4] Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu 610064, Sichuan, Peoples R China

[5] Sichuan Univ, West China Hosp, Psychiat Lab, Chengdu 610064, Sichuan, Peoples R China

[6] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610064, Sichuan, Peoples R China

[7] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai 200030, Peoples R China

[8] Tongde Hosp Zhejiang Prov, Dept Geriatr 1, Hangzhou, Zhejiang, Peoples R China

[9] Anhui Univ, Sch Life Sci, Hefei, Anhui, Peoples R China

来源：

NEUROBIOLOGY OF AGING | 2014年 / 35卷 / 02期

基金：

中国国家自然科学基金;

关键词：

LRRK2; Variants; Alzheimer's disease; Han Chinese; MUTATIONS; PARKINSONISM; COMMON; G2019S;

D O I：

10.1016/j.neurobiolaging.2013.08.013

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The leucine-rich repeat kinase-2 (LRRK2) gene has been regarded as 1 of the most common genetic causes of Parkinson's disease (PD). We hypothesized that LRRK2-susceptible allele(s) for PD might pose a risk for Alzheimer's disease (AD). In this study, we screened 12 LRRK2 gene variants in 2 independent cohorts from southwestern China (341 AD patients and 435 normal individuals) and eastern China (297 AD patients and 384 normal individuals), to discern the potential association between this gene and AD. No variant was identified to be associated with AD in either case-control sample. As both of the cohorts were of Han Chinese origin, we combined the LRRK2 variant data for the 2 sample sets together (a total of 638 AD patients and 819 normal individuals) and still found no association between the LRRK2 gene and AD, suggesting that LRRK2 gene variants may not affect the development of AD in Han Chinese individuals. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：444.e5 / 444.e9

页数：5

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