Biocatalysis in organic synthesis: The use of nitrile- and amide-hydrolyzing microorganisms

被引：127
作者：
Sugai, T
Yamazaki, T
Yokoyama, M
Ohta, H
机构：
[1] Department of Chemistry, Keio University, Yokohama, 223
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1997年 / 61卷 / 09期
关键词：
nitrile; amide; hydrolysis; microorganisms; organic synthesis;
D O I：
10.1271/bbb.61.1419
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review covers recent examples of synthetic transformation of nitriles and amides by microbial enzyme systems. A variety of substrates and products involving enantiomerically enriched forms of chiral substances are referred to. The stereochemical course of enzyme-catalyzed hydrolysis is briefly commented on. Special emphasis is placed upon the range of functional groups that are acceptable by enzymes and/or survive under the transformation, as well as the advantages as a synthetic tool for conversion under mild conditions.
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页码：1419 / 1427
页数：9
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