Quantitative analysis of radiation-induced chromosome aberrations

被引：20
|
作者：
Sachs, RK
Levy, D
Hahnfeldt, P
Hlatky, L
机构：
[1] Univ Calif Berkeley, Dept Math, Main Math Off, Berkeley, CA 94720 USA
[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA
来源：
CYTOGENETIC AND GENOME RESEARCH | 2004年 / 104卷 / 1-4期
关键词：
D O I：
10.1159/000077479
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We review chromosome aberration modeling and its applications, especially to biodosimetry and to characterizing chromosome geometry. Standard results on aberration formation pathways, randomness, dose-response, proximity effects, transmissibility, kinetics, and relations to other radiobiological endpoints are summarized. We also outline recent work on graph-theoretical descriptions of aberrations, Monte-Carlo computer simulations of aberration spectra, software for quantifying aberration complexity, and systematic links of apparently incomplete with complete or truly incomplete aberrations. Copyright (C) 2003 S. Karger AG, Basel.
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页码：142 / 148
页数：7
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