Metalloproteins and metal sensing

被引：995

作者：

Waldron, Kevin J. ^{[1
]}

Rutherford, Julian C. ^{[1
]}

Ford, Dianne ^{[1
]}

Robinson, Nigel J. ^{[1
]}

机构：

[1] Newcastle Univ, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

NATURE | 2009年 / 460卷 / 7257期

基金：

英国生物技术与生命科学研究理事会;

关键词：

TRANSCRIPTION FACTOR-I; HUMAN ZINC TRANSPORTER; SACCHAROMYCES-CEREVISIAE; COPPER HOMEOSTASIS; IRON-DEFICIENCY; DNA-BINDING; SCHIZOSACCHAROMYCES-POMBE; SUPEROXIDE-DISMUTASE; CARBONIC-ANHYDRASE; PLASMA-MEMBRANE;

D O I：

10.1038/nature08300

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Almost half of all enzymes must associate with a particular metal to function. An ambition is to understand why each metal-protein partnership arose and how it is maintained. Metal availability provides part of the explanation, and has changed over geological time and varies between habitats but is held within vital limits in cells. Such homeostasis needs metal sensors, and there is an ongoing search to discover the metal-sensing mechanisms. For metalloproteins to acquire the right metals, metal sensors must correctly distinguish between the inorganic elements.

引用

页码：823 / 830

页数：8

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