Biological impact of dosimetric perturbations of a fiducial marker and the daily number of fields in proton therapy for prostate cancer

The purpose of this study was to estimate the biological impact of dosimetric perturbations of a fiducial marker and the daily number of fields in proton therapy for prostate cancer. Using a linear-quadratic model, normalized total doses (NTDs) of points where deposited dose was reduced from the prescribed dose by dosimetric perturbation of a fiducial marker were calculated in two hypothetical prostate cancer treatment schedules: a) irradiation of both parallel-opposed lateral fields and b) irradiation of alternate field in each daily treatment. The impact of hypofractionation and sublethal damage repair between irradiation on NTD was also estimated. The NTD of two fields/day schedule becomes lower than that of one field/day schedule. The difference becomes larger as dose reduction from one of two fields becomes more enhanced. The NTD reduction from the total dose in the two fields/day schedule is largest (30% of total dose) where the dose from one beam is completely lost by a fiducial marker. In contrast, the NTD reduction from the total dose in the one field/day schedule is largest (9% of total dose) where the half dose from one beam is decreased by a fiducial marker. In addition, the NTD reduction becomes larger as the fractional dose increases in a hypofractionated regimen, and when the effect of sublethal damage repair was incorporated. These influences become significant in prostate cancer since the radiobiological sensitivity alpha/beta of prostate cancer is lower than other cancer types and normal tissues late complication. Treating with one alternate field in a daily treatment can improve a deteriorating treatment effect by dosimetric distortion of a fiducial marker in prostate cancer treatment. However, the choice of the number of beams in a fraction must also be determined by considering the sparing of normal tissues and patient-specific status.