Surgical Approach and Long-term Clinical Outcome in Women with Microinvasive Cervical Cancer

被引：0

作者：

Sopracordevole, Francesco ^{[1
]}

Chiossi, Giuseppe ^{[2
]}

Barbero, Maggiorino ^{[3
]}

Cristoforoni, Paolo ^{[4
]}

Ghiringhello, Bruno ^{[5
]}

Frega, Antonio ^{[6
]}

Tortolani, Francesca ^{[2
]}

Boselli, Fausto ^{[2
]}

Clemente, Nicolo ^{[7
]}

Ciavattini, Andrea ^{[7
]}

机构：

[1] Ctr Riferimento Oncol, Dept Gynecol Oncol, Aviano, Italy

[2] Univ Modena & Reggio Emilia, Dept Gynaecol Obstetr & Pediat Sci, Sect Gynaecol, Modena, Italy

[3] Asti Community Hosp, Dept Obstet & Gynecol, Asti, Italy

[4] Univ Genoa, Dept Obstet & Gynecol, Genoa, Italy

[5] Univ Turin, Dept Pathol, Turin, Italy

[6] Univ Roma La Sapienza, Clin Obstet & Gynaecol 2, I-00185 Rome, Italy

[7] Polytech Univ Marche, Gynecol Sect, Womans Hlth Sci Dept, Ancona, Italy

来源：

ANTICANCER RESEARCH | 2014年 / 34卷 / 08期

关键词：

Conization; microinvasive cervical cancer; cone margins; lymph vascular space invasion; SQUAMOUS-CELL CARCINOMA; VASCULAR SPACE INVASION; UTERINE CERVIX; INTERNATIONAL FEDERATION; STAGE IA(1); SURGERY; MANAGEMENT; INVOLVEMENT; CONIZATION; GYNECOLOGY;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To assess the efficacy and safety of conservative surgical approach for microinvasive cervical cancer with regards to cone margins status and lymph vascular space invasion (LVSI). Patients and Methods: This was a multicentre retrospective cohort study of 153 women diagnosed with microinvasive cervical cancer over a 10 years period (1993-2003). Results: In conservatively-treated women (n=80), neither cancer mortality nor disease relapse after 184.5 +/- 20.5 months of follow-up was detected. Residual disease in women who underwent secondary surgery was significantly related to positive margins on the primary cone excision (p=0.005) while no correlation with LVSI emerged. Conclusion: Conization can represent the definitive treatment for stage IA1, if surgical margins are cancer-free, independently of LVSI. A conservative surgical approach could also be considered in women with IA2 cervical cancer when preservation of fertility is strongly requested. A close long-term surveillance should be scheduled for conservatively-treated women

引用

页码：4345 / 4349

页数：5

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