Cerebrospinal Fluid Aquaporin-4 Antibody Levels in Neuromyelitis Optica Attacks

被引：45

作者：

Sato, Douglas Kazutoshi ^{[1
]}

Callegaro, Dagoberto ^{[2
]}

de Haidar Jorge, Frederico M. ^{[2
]}

Nakashima, Ichiro ^{[1
]}

Nishiyama, Shuhei ^{[1
]}

Takahashi, Toshiyuki ^{[1
]}

Simm, Renata Faria ^{[2
]}

Apostolos-Pereira, Samira Luisa ^{[2
]}

Misu, Tatsuro ^{[3
]}

Steinman, Lawrence ^{[4
]}

Aoki, Masashi ^{[1
]}

Fujihara, Kazuo ^{[3
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Neurol, Sendai, Miyagi 9808574, Japan

[2] Univ Sao Paulo, Fac Med, Dept Neurol, Sao Paulo, Brazil

[3] Tohoku Univ, Dept Multiple Sclerosis Therapeut, Grad Sch Med, Sendai, Miyagi 980, Japan

[4] Stanford Univ, Dept Pediat Neurol & Neurol Sci, Stanford, CA 94305 USA

来源：

ANNALS OF NEUROLOGY | 2014年 / 76卷 / 02期

关键词：

DIAGNOSTIC-CRITERIA; DISTINCTION; LESIONS; MARKER; NMO;

D O I：

10.1002/ana.24208

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To elucidate immunopathogenetic roles of aquaporin-4 antibodies in the cerebrospinal fluid (CSF) of neuromyelitis optica spectrum disorders (NMOSD), we analyzed aquaporin-4 antibody titers, cellular and inflammatory markers in the CSF collected from 11 aquaporin-4 antibody seropositive patients. The CSF aquaporin-4 antibody levels during attacks (but not in sera) closely correlated with pleocytosis, inflammatory cytokines including interleukin-6 that can regulate antibody-producing plasmablasts, and glial fibrillary acidic protein levels in the CSF. The amount of aquaporin-4 antibodies present in the central nervous system may have therapeutic implications, as it is associated with astrocyte injury and inflammatory responses during NMOSD attacks.

引用

页码：305 / 309

页数：5

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