Systematic review and meta-analysis of appendiceal carcinoid tumors in children

被引:34
作者
Njere, Ike [1 ]
Smith, Lisa Linnea [1 ]
Thurairasa, Dushanthi [1 ]
Malik, Rubina [2 ]
Jeffrey, Iona [3 ]
Okoye, Bruce [1 ]
Sinha, Chandrasen [1 ]
机构
[1] St Georges Univ Hosp NHS Fdn Trust, Dept Paediat Surg, Blackshaw Rd,Tooting Broadway, London SW17 0QT, England
[2] Royal Marsden Hosp, Dept Paediat Oncol, Sutton, Surrey, England
[3] St Georges Univ Hosp NHS Fdn Trust, Dept Histopathol, London, England
关键词
appendix; carcinoid; children; mortality; recurrence; RHC; NEUROENDOCRINE-TUMORS; SINGLE-INSTITUTION; EXPERIENCE; MANAGEMENT; CHILDHOOD; APPENDECTOMY; MALIGNANCIES; ADOLESCENTS; OUTCOMES;
D O I
10.1002/pbc.27069
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
ObjectiveThe study's aim was to review the literature regarding past and current practices in managing incidental appendiceal carcinoid tumors and need for more procedures. MethodA search of MEDLINE, Embase, CINAHL, and Cochrane databases of systematic reviews was undertaken of the English language literature. The mesh terms used were carcinoid or neuroendocrine, tumour or tumor, appendix, appendicectomy, or appendectomy, and child, pediatric, or paediatric. Of the 369 articles found, 37 met the inclusion criteria. Our hospital records and pathology database identified 11 patients with confirmed histological diagnosis of appendicular carcinoids from January 1996 to December 2016. Those cases were also included in this study. ResultsA total of 958 cases were identified from the literature and our own experience. There were 566 females and 343 males giving us a ratio of 1.65:1. The frequency was 0.3% of appendicectomies. There was a 28-fold increase in the risk of having a positive lymph node if the tumor size was>2cm compared with the risk of having a positive lymph node if the tumor size was 2cm. There was no recurrence or mortality for those with criteria for secondary surgery, who were observed after appendicectomy compared to those that had secondary surgery. Mean follow-up was 58.6 months (4.8 years) with a range of 0-396 months (33 years). ConclusionAppendicectomy alone is an adequate treatment for an appendicular carcinoid in children irrespective of size, position, lymph node, or mesenteric involvement. Post-appendicectomy investigations were found to be not helpful in this study.
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页数:9
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