Comparison of different properties -: log P, log kw, and φ0 -: as descriptors of the hydrophobicity of some fungicides

Log P, log k(w), and phi(0), are proposed and compared as descriptors of the hydrophobicity of twenty-two dihydroxythiobenzanilides organic substances with antifungal properties. The log P values were calculated using theoretical methods proposed at http://146.107.217.178/lab/alogps. Chromatographic data log k(w) and phi(0), were calculated from experimental TLC results obtained on RP-18W and RP-CN bonded stationary phases with methanol or acetone as organic modifiers. In addition to extrapolation, a numerical method based on Oscik's linear equation was used for calculation of log k(w) values. The effect of mobile and stationary phase properties on the chromatographic data was studied and calculated hydrophobicity was compared with the biological activity of the test substances.