Prospects for the therapeutic development of umbilical cord blood-derived mesenchymal stem cells

被引：26

作者：

Um, Soyoun ^{[1
]}

Ha, Jueun ^{[1
]}

Choi, Soo Jin ^{[2
]}

Oh, Wonil ^{[2
]}

Jin, Hye Jin ^{[2
]}

机构：

[1] MEDIPOST Co Ltd, Biomed Res Inst, Res Team Immune Cell Therapy, Seongnam 13494, South Korea

[2] MEDIPOST Co Ltd, Biomed Res Inst, 21 Daewangpangyo Ro 644 Gil, Seongnam 13494, South Korea

来源：

WORLD JOURNAL OF STEM CELLS | 2020年 / 12卷 / 12期

关键词：

Umbilical cord blood; Mesenchymal stem cell; Stem cell therapy; Immunomodulation; Regenerative medicine; Therapeutic cell manufacturing processing; HUMAN BONE-MARROW; STROMAL CELLS; CHONDROGENIC DIFFERENTIATION; OSTEOGENIC DIFFERENTIATION; IN-VITRO; ADIPOSE-TISSUE; IMMUNOLOGICAL-PROPERTIES; TELOMERASE ACTIVITY; GENE-THERAPY; TRANSPLANTATION;

D O I：

10.4252/wjsc.v12.i12.1511

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Umbilical cord blood (UCB) is a primitive and abundant source of mesenchymal stem cells (MSCs). UCB-derived MSCs have a broad and efficient therapeutic capacity to treat various diseases and disorders. Despite the high latent self-renewal and differentiation capacity of these cells, the safety, efficacy, and yield of MSCs expanded for ex vivo clinical applications remains a concern. However, immunomodulatory effects have emerged in various disease models, exhibiting specific mechanisms of action, such as cell migration and homing, angiogenesis, anti-apoptosis, proliferation, anti-cancer, anti-fibrosis, anti-inflammation and tissue regeneration. Herein, we review the current literature pertaining to the UCB-derived MSC application as potential treatment strategies, and discuss the concerns regarding the safety and mass production issues in future applications.

引用

页码：1511 / 1528

页数：18

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