Extracts from St John's Wort and their antimicrobial activity

被引：82

作者：

Avato, P ^{[1
]}

Raffo, F ^{[1
]}

Guglielmi, G ^{[1
]}

Vitali, C ^{[1
]}

Rosato, A ^{[1
]}

机构：

[1] Dipartimento Farmacochim, I-70125 Bari, Italy

来源：

PHYTOTHERAPY RESEARCH | 2004年 / 18卷 / 03期

关键词：

Hypericum perforatum; St John's Wort; antimicrobial activity; Gram positive; hypericin; hyperforin;

D O I：

10.1002/ptr.1430

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In an effort to carry out a more in-depth investigation on the antimicrobial properties of H. perforatum, we have assayed different extracts (MeOH; petroleum ether; CHCl3 and EtOAc) from the aerial parts of the plant against selected microorganisms. Growth inhibition was observed only for Gram-positive bacteria, R subtilis and R cereus being the most susceptible to the tested drugs. The Hypericum extract obtained with EtOAc was the most active. The main constituents of this extract, as determined by HPLC analysis, were flavonoids, hypericins and hyperforins. Incubation of the selected microorganisms with the pure chemicals resulted in a significant inhibition of their growth by hypericin, hyperforin and its stable dicyclohexilammonium salt. Flavonoids appeared inactive at all. Copyright (C) 2004 John Wiley Sons, Ltd.

引用

页码：230 / 232

页数：3

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