HCC-Derived Exosomes: Critical Player and Target for Cancer Immune Escape

被引：103

作者：

Han, Qiuju ^{[1
]}

Zhao, Huajun ^{[1
]}

Jiang, Yu ^{[1
]}

Yin, Chunlai ^{[1
]}

Zhang, Jian ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Inst Immunopharmaceut Sci, 44 Wenhua West Rd, Jinan 250012, Shandong, Peoples R China

来源：

CELLS | 2019年 / 8卷 / 06期

基金：

中国国家自然科学基金;

关键词：

HCC; exosome; immune escape; miRNA; HEPATOCELLULAR-CARCINOMA; T-CELL; TUMOR; METASTASIS; MICRORNA; CYTOTOXICITY; MODULATION; MECHANISMS; RESPONSES; PROTEINS;

D O I：

10.3390/cells8060558

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hepatocellular carcinoma (HCC) is a primary malignancy of the liver, and currently the second most common cause of cancer-related deaths worldwide with increasing incidence and poor prognosis. Exosomes are now considered as important mediators of host anti-tumor immune response as well as tumor cell immune escape. HCC-derived exosomes have been shown to attenuate the cytotoxicity of T-cells and NK cells, and promote the immuno-suppressive M2 macrophages, N2 neutrophils, and Bregs. These exosomes harbor several immune-related non-coding RNAs and proteins that drive immune-escape and tumor progression, and thus may serve as potential diagnostic biomarkers and therapeutic targets for HCC. In a previous study, we identified miR146a as an exosomal factor that promotes M2-polarization and suppresses the anti-HCC function of T-cells. In this review, we summarized the role of tumor-derived exosomes and their key components in mediating tumor immune escape during HCC development.

引用

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