Effects of ochratoxin A on oxidative damage in rat kidney:: Protective role of melatonin

被引：33

作者：

Özçelik, N

Soyöz, M

Kilinç, I

机构：

[1] Suleyman Demirel Univ, Fac Med, Dept Med Biol & Genet, TR-32260 Isparta, Turkey

[2] Suleyman Demirel Univ, Fac Med, Dept Biochem & Clin Biochem, TR-32260 Isparta, Turkey

来源：

JOURNAL OF APPLIED TOXICOLOGY | 2004年 / 24卷 / 03期

关键词：

ochratoxin A; melatonin; kidney; lipid peroxidation; superoxide dismutase; catalase; glutathione peroxidase;

D O I：

10.1002/jat.974

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Epidemiological studies indicate that ochratoxin A (OTA) may be involved in the pathogenesis of different forms of human nephropathies. Melatonin (MEL) displays antioxidant and free radical scavenger properties. In the present study, the effect of MEL on the oxidative stress induced by OTA administration in rats was investigated. Three groups of eight rats each were used: control, OTA (289 mug kg(-1) day) and OTA + MEL (OTA, 289 mug kg(-1) day(-1); MEL, 10 mg kg(-1) day(-1)), with treatment at two different time periods during the same day. After 4 weeks of treatment, the levels of lipid peroxidation (LPO) and the activities of catalase, superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) were measured in homogenates of kidney. In OTA-treated rats, the levels of LPO and the activities of GSHPx and SOD were significantly decreased compared with controls. In OTA + MEL-treated rats, SOD, GSHPx and catalase activities and LPO levels were not changed significantly in comparison with controls. Copyright (C) 2004 John Wiley Sons, Ltd.

引用

页码：211 / 215

页数：5

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