Neurobiology of rodent self-grooming and its value for translational neuroscience

被引：575

作者：

Kalueff, Allan V. ^{[1
,2
,3
,4
,5
]}

Stewart, Adam Michael ^{[2
]}

Song, Cai ^{[1
,6
,7
]}

Berridge, Kent C. ^{[8
]}

Graybiel, Ann M. ^{[9
,10
]}

Fentress, John C. ^{[6
]}

机构：

[1] Guangdong Ocean Univ, Coll Food Sci & Technol, Res Inst Marine Drugs & Nutr, Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China

[2] ZENEREI Res Ctr, Neurosci Res Lab, Slidell, LA 70458 USA

[3] St Petersburg State Univ, Inst Translat Biomed, St Petersburg 199034, Russia

[4] Ural Fed Univ, Inst Chem Technol, Ekaterinburg 620002, Russia

[5] Ural Fed Univ, Inst Nat Sci, Ekaterinburg 620002, Russia

[6] Dalhousie Univ, Dept Psychol & Neurosci, Halifax, NS B3H 4R2, Canada

[7] China Med Univ, Grad Inst Neural Cognit Sci, Taichung 000001, Taiwan

[8] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA

[9] MIT, McGovern Inst Brain Res, Cambridge, MA 02139 USA

[10] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2016年 / 17卷 / 01期

基金：

美国国家卫生研究院;

关键词：

OBSESSIVE-COMPULSIVE-DISORDER; SEROTONIN TRANSPORTER GENE; AUTISM SPECTRUM DISORDERS; COMPLEX MOVEMENT SEQUENCE; TRANSGENIC MOUSE MODEL; VOLE MICROTUS-AGRESTIS; REPETITIVE BEHAVIORS; BASAL GANGLIA; TOURETTE SYNDROME; MICE LACKING;

D O I：

10.1038/nrn.2015.8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing pattern and is one of the most frequently performed behavioural activities in rodents. In this Review, we discuss the neurobiology of rodent self-grooming, and we highlight studies of rodent models of neuropsychiatric disorders - including models of autism spectrum disorder and obsessive compulsive disorder - that have assessed self-grooming phenotypes. We suggest that rodent self-grooming may be a useful measure of repetitive behaviour in such models, and therefore of value to translational psychiatry. Assessment of rodent self-grooming may also be useful for understanding the neural circuits that are involved in complex sequential patterns of action.

引用

页码：45 / 59

页数：15

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