Hispolon suppresses migration and invasion of human nasopharyngeal carcinoma cells by inhibiting the urokinase-plasminogen activator through modulation of the Akt signaling pathway

被引：30

作者：

Ho, Hsin-Yu ^{[1
]}

Ho, Yung-Chuan ^{[2
]}

Hsieh, Ming-Ju ^{[1
,3
]}

Yang, Shun-Fa ^{[1
,4
]}

Chuang, Chun-Yi ^{[5
,6
]}

Lin, Chiao-Wen ^{[7
,8
]}

Hsin, Chung-Han ^{[5
,6
]}

机构：

[1] Chung Shan Med Univ, Inst Med, Taichung, Taiwan

[2] Chung Shan Med Univ, Sch Appl Chem, Taichung, Taiwan

[3] Changhua Christian Hosp, Canc Res Ctr, Changhua, Taiwan

[4] Chung Shan Med Univ Hosp, Dept Med Res, Taichung, Taiwan

[5] Chung Shan Med Univ, Sch Med, Taichung, Taiwan

[6] Chung Shan Med Univ Hosp, Dept Otolaryngol, Taichung, Taiwan

[7] Chung Shan Med Univ, Inst Oral Sci, 110 Chien Kuo N Rd,Sect 1, Taichung, Taiwan

[8] Chung Shan Med Univ Hosp, Dept Dent, Taichung, Taiwan

来源：

ENVIRONMENTAL TOXICOLOGY | 2017年 / 32卷 / 02期

关键词：

hispolon; uPA; migration; nasopharyngeal carcinoma; TPA-INDUCED INVASION; MATRIX METALLOPROTEINASE-2; DOWN-REGULATION; CYCLE ARREST; CANCER CELLS; TUMOR-GROWTH; APOPTOSIS; METASTASIS; EXPRESSION; PROGNOSIS;

D O I：

10.1002/tox.22266

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Hispolon has been reported to possess antioxidant, antiinflammatory, and antitumor activities. However, the effect of hispolon on the metastasis of nasopharyngeal carcinoma (NPC) remains unclear. In this study, we investigated how the antimetastatic activity and relevant signaling pathways of hispolon affected three NPC cell lines. The results revealed that hispolon significantly reduced the migration and invasion of three NPC cells in a dose-dependent manner from 0 to 50 mu M. Hispolon also significantly inhibited the activity and expression of urokinase-plasminogen activator (uPA) as well as the phosphorylation of Akt. Moreover, blocking the Akt pathway also enhanced the antimetastatic ability of hispolon in the NPC cells. In conclusion, hispolon inhibited uPA expression and NPC cell metastasis by downregulating Akt signal pathways; therefore, hispolon exerts beneficial effects in chemoprevention. (c) 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 645-655, 2017.

引用

页码：645 / 655

页数：11

共 41 条

[1] Blueberry Phytochemicals Inhibit Growth and Metastatic Potential of MDA-MB-231 Breast Cancer Cells through Modulation of the Phosphatidylinositol 3-Kinase Pathway [J].