Astrocytes and Microglia and Their Potential Link with Autism Spectrum Disorders

被引：130

作者：

Petrelli, Francesco ^{[1
]}

Pucci, Luca ^{[1
]}

Bezzi, Paola ^{[1
]}

机构：

[1] Univ Lausanne, Dept Fundamental Neurosci, Lausanne, Switzerland

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2016年 / 10卷

关键词：

astrocytes; microglia; neurosciences; autism spectrum disorders (ASD); MATERNAL IMMUNE ACTIVATION; BRAIN-DEVELOPMENT; RETT-SYNDROME; MOUSE MODEL; AUTOIMMUNE-DISEASES; SECRETED PROTEINS; DENDRITIC CELLS; ASSOCIATION; NEURONS; GLIA;

D O I：

10.3389/fncel.2016.00021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The cellular mechanism(s) underlying autism spectrum disorders (ASDs) are not fully understood although it has been shown that various genetic and environmental factors contribute to their etiology. As increasing evidence indicates that astrocytes and microglial cells play a major role in synapse maturation and function, and there is evidence of deficits in glial cell functions in ASDs, one current hypothesis is that glial dysfunctions directly contribute to their pathophysiology. The aim of this review is to summarize microglia and astrocyte functions in synapse development and their contributions to ASDs.

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页数：8

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