Not just amyloid: physiological functions of the amyloid precursor protein family

被引：425

作者：

Mueller, Ulrike C. ^{[1
]}

Deller, Thomas ^{[2
]}

Korte, Martin ^{[3
,4
]}

机构：

[1] Heidelberg Univ, Inst Pharm & Mol Biotechnol, Bioinformat & Funct Genom, Neuenheimer Feld 364, D-69120 Heidelberg, Germany

[2] Goethe Univ Frankfurt, Inst Clin Neuroanat, Neurosci Ctr, Theodor Stern Kai 7, D-60590 Frankfurt, Germany

[3] TU Braunschweig, Zool Inst, Cellular Neurobiol, Spielmannstr 7, D-38106 Raunschweig, Germany

[4] Helmholtz Ctr Infect Res, Neuroinflammat & Neurodegenerat Grp, Inhoffenstr 7, D-38124 Braunschweig, Germany

来源：

NATURE REVIEWS NEUROSCIENCE | 2017年 / 18卷 / 05期

关键词：

TRAUMATIC BRAIN-INJURY; LONG-TERM POTENTIATION; HIPPOCAMPAL SYNAPTIC PLASTICITY; RIBOSYLATION FACTOR 6; BETA-PP-ALPHA; ALZHEIMERS-DISEASE; MICE LACKING; APPS-ALPHA; CRYSTAL-STRUCTURE; GENE-EXPRESSION;

D O I：

10.1038/nrn.2017.29

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Amyloid precursor protein (APP) gives rise to the amyloid-beta peptide and thus has a key role in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP and the closely related APP-like proteins (APLPs) remain less well understood. Studying these physiological functions has been challenging and has required a careful long-term strategy, including the analysis of different App-knockout and Aplp-knockout mice. In this Review, we summarize these findings, focusing on the in vivo roles of APP family members and their processing products for CNS development, synapse formation and function, brain injury and neuroprotection, as well as ageing. In addition, we discuss the implications of APP physiology for therapeutic approaches.

引用

页码：281 / 298

页数：18

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