Facile entries for regioselective synthesis of [1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones from 2-thiouracil

被引：11

作者：

Shawali, A. S. ^{[1
]}

Abbas, I. M.

Mahran, A. M.

机构：

[1] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt

[2] Natl Res Ctr, Giza, Egypt

来源：

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY | 2004年 / 1卷 / 01期

关键词：

heterocycles; hydrazones; rearrangement; synthetic methods; 1,2,4-triazolo-pyrimidine;

D O I：

10.1007/BF03245768

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three new alternative synthetic strategies based on reactions of hydrazonoyl halides 3 with 2-methylthiouracil 2 and treatment of either 2-pyrimidinyl thiohydrazonates 8 or the diazonium coupling products of active (pyrimidin-2-ylthio)methylene compounds 12 with sodium ethoxide in ethanol are described for the title compounds. The mechanisms and regiochemistry of the studied reactions are discussed.

引用

页码：33 / 39

页数：7

共 26 条

[21] ON TRIAZOLES .11. STRUCTURE ELUCIDATION OF ISOMERIC 1,2,4-TRIAZOLOPYRIMIDINONES [J].